Cell Biology Antibodies 17

Anti-TXNRD2 Antibody (CAB8884)

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SKU:
CAB8884
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TXNRD2 Antibody
Antibody SKU:CAB8884
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TXNRD2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Mouse liver, Mouse spleen, Mouse kidney
Immunogen:A synthesized peptide derived from human TXNRD2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10587
Uniprot:Q9NNW7
Cellular Location:
Calculated MW:57kDa
Observed MW:56KDa
Synonyms:SELZ, TR, TR-BETA, TR3, TRXR2
Background:This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
UniProt Protein Function:TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function:FAD binding; protein binding; thioredoxin-disulfide reductase activity

Biological Process: cell redox homeostasis; response to oxygen radical; response to reactive oxygen species

NCBI Summary:This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
UniProt Code:Q9NNW7
NCBI GenInfo Identifier:182705230
NCBI Gene ID:10587
NCBI Accession:Q9NNW7.3
UniProt Secondary Accession:Q9NNW7,O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0 Q9P2Y1, Q9UQU8,
UniProt Related Accession:Q9NNW7
Molecular Weight:30,291 Da
NCBI Full Name:Thioredoxin reductase 2, mitochondrial
NCBI Synonym Full Names:thioredoxin reductase 2
NCBI Official Symbol:TXNRD2  
NCBI Official Synonym Symbols:TR; TR3; SELZ; TRXR2; TR-BETA  
NCBI Protein Information:thioredoxin reductase 2, mitochondrial
UniProt Protein Name:Thioredoxin reductase 2, mitochondrial
UniProt Synonym Protein Names:Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
Protein Family:Thioredoxin reductase
UniProt Gene Name:TXNRD2  
UniProt Entry Name:TRXR2_HUMAN
Anti-TXNRD2 Antibody (CAB8884)Western blot - TXNRD2 Rabbit mAb (CAB8884)
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