Cell Cycle Antibodies 2
Anti-TXNIP Antibody (CAB9342)
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- SKU:
- CAB9342
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-TXNIP Antibody |
| Antibody SKU: | CAB9342 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human TXNIP (NP_006463.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human TXNIP (NP_006463.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVMF KKIK SFEV VFND PEKV YGSG EKVA GRVI VEVC EVTR VKAV RILA CGVA KVLW MQGS QQCK QTSE YLRY EDTL LLED QPTG ENEM VIMR PGNK YEYK FGFE LPQG PLGT SFKG KYGC VDYW VKAF LDRP SQPT QETK KNFE VVDL VDVN TPDL MAPV SAKK EK |
| Gene ID: | 10628 |
| Uniprot: | Q9H3M7 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 37kDa/43kDa |
| Observed MW: | 45kDa |
| Synonyms: | TXNIP, ARRDC6, EST01027, HHCPA78, THIF, VDUP1 |
| Background: | This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| NCBI Summary: | This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9H3M7 |
| NCBI GenInfo Identifier: | 928192549 |
| NCBI Gene ID: | 10628 |
| NCBI Accession: | NP_001300901.1 |
| UniProt Secondary Accession: | Q9H3M7,Q16226, Q6PML0, Q9BXG9, B4E3D3, |
| UniProt Related Accession: | Q9H3M7 |
| Molecular Weight: | 37,319 Da |
| NCBI Full Name: | thioredoxin-interacting protein isoform 2 |
| NCBI Synonym Full Names: | thioredoxin interacting protein |
| NCBI Official Symbol: | TXNIP |
| NCBI Official Synonym Symbols: | THIF; VDUP1; ARRDC6; HHCPA78; EST01027 |
| NCBI Protein Information: | thioredoxin-interacting protein |
| UniProt Protein Name: | Thioredoxin-interacting protein |
| UniProt Synonym Protein Names: | Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1 |
| Protein Family: | TATA-binding protein |
| UniProt Gene Name: | TXNIP |
 | Western blot analysis of extracts of various cell lines, using TXNIP antibody (CAB9342) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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