KO Validated Antibodies 2

Anti-TXNDC5 Antibody (CAB19930)[KO Validated]

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SKU:
CAB19930
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TXNDC5 Antibody [KO Validated]
Antibody SKU:CAB19930
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human TXNDC5.
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human TXNDC5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:81567
Uniprot:Q8NBS9
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:36kDa/47kDa
Observed MW:50KDa
Anti-TXNDC5 Antibody [KO Validated] (CAB19930)Western blot analysis of extracts from normal (control) and TXNDC5 knockout (KO) 293T cells, using TXNDC5 antibody (CAB19930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:TXNDC5, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364
Background:This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene.
UniProt Protein Function:TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen

Molecular Function:protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
UniProt Code:Q8NBS9
NCBI GenInfo Identifier:29839560
NCBI Gene ID:81567
NCBI Accession:Q8NBS9.2
UniProt Related Accession:Q8NBS9
Molecular Weight:
NCBI Full Name:Thioredoxin domain-containing protein 5
NCBI Synonym Full Names:thioredoxin domain containing 5
NCBI Official Symbol:TXNDC5  
NCBI Official Synonym Symbols:HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI  
NCBI Protein Information:thioredoxin domain-containing protein 5
UniProt Protein Name:Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names:Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
UniProt Gene Name:TXNDC5  
UniProt Entry Name:TXND5_HUMAN
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