Cell Biology Antibodies 3
Anti-TXN2 Antibody (CAB12591)
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- SKU:
- CAB12591
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TXN2 Antibody |
| Antibody SKU: | CAB12591 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human TXN2 (NP_036605.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, 293T, SW620, Mouse liver, Mouse brain, Mouse bone marrow |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human TXN2 (NP_036605.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQR LLLR RFLA SVIS RKPS QGQW PPLT SRAL QTPQ CSPG GLTV TPNP ARTI YTTR ISLT TFNI QDGP DFQD RVVN SETP VVVD FHAQ WCGP CKIL GPRL EKMV AKQH GKVV MAKV DIDD HTDL AIEY EVSA VPTV LAMK NGDV VDKF VGIK DEDQ LEAF LKKL IG |
| Gene ID: | 25828 |
| Uniprot: | Q99757 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 18kDa |
| Observed MW: | 13kDa |
| Synonyms: | TXN2, COXPD29, MT-TRX, MTRX, TRX2, TXN |
| Background: | This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. |
| UniProt Protein Function: | TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus Molecular Function:peptide-methionine-(S)-S-oxide reductase activity; protein complex binding; protein disulfide oxidoreductase activity; peptide-methionine (R)-S-oxide reductase activity Biological Process: response to drug; cellular response to nutrient levels; response to reactive oxygen species; cell redox homeostasis; response to hormone stimulus; response to glucose stimulus; response to hypoxia; response to axon injury; response to organic cyclic substance; glycerol ether metabolic process; response to nutrient |
| NCBI Summary: | This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99757 |
| NCBI GenInfo Identifier: | 20455529 |
| NCBI Gene ID: | 25828 |
| NCBI Accession: | Q99757.2 |
| UniProt Secondary Accession: | Q99757,Q5JZA0, Q6FH60, Q9UH29, |
| UniProt Related Accession: | Q99757 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin, mitochondrial |
| NCBI Synonym Full Names: | thioredoxin 2 |
| NCBI Official Symbol: | TXN2 |
| NCBI Official Synonym Symbols: | MTRX; TRX2; MT-TRX |
| NCBI Protein Information: | thioredoxin, mitochondrial; thioredoxin-2; mitochondrial thioredoxin |
| UniProt Protein Name: | Thioredoxin, mitochondrial |
| UniProt Synonym Protein Names: | Thioredoxin-2 |
| UniProt Gene Name: | TXN2 |
| UniProt Entry Name: | THIOM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TXN2 antibody (CAB12591) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using TXN2 antibody (CAB12591) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TXN2 antibody (CAB12591) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using TXN2 antibody (CAB12591) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using TXN2 antibody (CAB12591) at dilution of 1:100 (40x lens). |
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