Signal Transduction Antibodies 1
Anti-TUSC3 Antibody (CAB12571)
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- SKU:
- CAB12571
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TUSC3 Antibody |
| Antibody SKU: | CAB12571 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-200 of human TUSC3 (NP_839952.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | 22Rv1, LO2, A-549, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-200 of human TUSC3 (NP_839952.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QKKK ENLL AEKV EQLM EWSS RRSI FRMN GDKF RKFI KAPP RNYS MIVM FTAL QPQR QCSV CRQA NEEY QILA NSWR YSSA FCNK LFFS MVDY DEGT DVFQ QLNM NSAP TFMH FPPK GRPK RADT FDLQ RIGF AAEQ LAKW IADR TDVH IRVF RPPN YSG |
| Gene ID: | 7991 |
| Uniprot: | Q13454 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 38kDa |
| Synonyms: | TUSC3, D8S1992, M33, MRT22, MRT7, N33, OST3A |
| Background: | This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | TUSC3: Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. Defects in TUSC3 are the cause of mental retardation autosomal recessive type 7 (MRT7); also known as mental retardation non-syndromic autosomal recessive 7. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the OST3/OST6 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p22 Cellular Component: endoplasmic reticulum membrane; mitochondrion; oligosaccharyl transferase complex; plasma membrane Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; magnesium ion transmembrane transporter activity Biological Process: cognition; magnesium ion transport; protein amino acid N-linked glycosylation via asparagine; transmembrane transport Disease: Mental Retardation, Autosomal Recessive 7 |
| NCBI Summary: | This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13454 |
| NCBI GenInfo Identifier: | 6166601 |
| NCBI Gene ID: | 7991 |
| NCBI Accession: | Q13454.1 |
| UniProt Secondary Accession: | Q13454,Q14911, Q14912, Q96FW0, A8MSM0, D3DSP2, |
| UniProt Related Accession: | Q13454 |
| Molecular Weight: | 40kDa |
| NCBI Full Name: | Tumor suppressor candidate 3 |
| NCBI Synonym Full Names: | tumor suppressor candidate 3 |
| NCBI Official Symbol: | TUSC3 |
| NCBI Official Synonym Symbols: | M33; N33; MRT7; MRT22; OST3A; D8S1992 |
| NCBI Protein Information: | tumor suppressor candidate 3 |
| UniProt Protein Name: | Tumor suppressor candidate 3 |
| UniProt Synonym Protein Names: | Magnesium uptake/transporter TUSC3; Protein N33 |
| Protein Family: | Tumor suppressor candidate |
| UniProt Gene Name: | TUSC3 |
 | Western blot analysis of extracts of various cell lines, using TUSC3 antibody (CAB12571) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 10s. |
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