Cell Biology Antibodies 6
Anti-TUBGCP6 Antibody (CAB15921)
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- SKU:
- CAB15921
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TUBGCP6 Antibody |
| Antibody SKU: | CAB15921 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human TUBGCP6 (NP_065194.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human TUBGCP6 (NP_065194.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KTIN LLKL CCPR HYLC WSDV PVPR ISVI FSLE ELKE IEKD CAVY VGRM ERVA RHSS VSKE EKEL RMEI AKQE LIAH AREA ASRV LSAL SDRQ MSER MALD ARKR EQFQ RLKE QFVK DQER RQAA RQEE LDDD FSYA RELR DRER RLKS LEEE LERK ARQA LVDH YSKL SAEA ARRE QKAL WRIQ RHRL ESAR LRFL LEDE KHIQ EMLK AVSE AHQP QEPP DVLL SVHP QVTS PGPE HPEG GQGC DSGS AEQH SPAW DGWN RPGL LTPQ PLKP LAVG AGGR GLQQ AEGA RPFS DSLS IGDF L |
| Gene ID: | 85378 |
| Uniprot: | Q96RT7 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 196kDa/198kDa/200kDa |
| Observed MW: | 250kDa |
| Synonyms: | TUBGCP6, GCP-6, GCP6, MCCRP, MCCRP1, MCPHCR |
| Background: | The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. |
| UniProt Protein Function: | GCP6: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Defects in TUBGCP6 are the cause of microcephaly with chorioretinopathy, autosomal recessive (MCPHCR). A syndrome characterized by microcephaly, cognitive impairment, underdeveloped retina and choroid, and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident during the first year of life. Belongs to the TUBGCP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q13.31-q13.33 Cellular Component: centrosome; cytosol; gamma-tubulin ring complex; membrane; microtubule; spindle pole body Molecular Function:gamma-tubulin binding; microtubule binding; microtubule minus-end binding; structural constituent of cytoskeleton Biological Process: centrosome duplication; cytoplasmic microtubule organization and biogenesis; G2/M transition of mitotic cell cycle; interphase microtubule nucleation by interphase microtubule organizing center; meiosis; microtubule nucleation; mitotic cell cycle Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive 1 |
| NCBI Summary: | The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RT7 |
| NCBI GenInfo Identifier: | 143811395 |
| NCBI Gene ID: | 85378 |
| NCBI Accession: | Q96RT7.3 |
| UniProt Secondary Accession: | Q96RT7,Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4 |
| UniProt Related Accession: | Q96RT7 |
| Molecular Weight: | 198,761 Da |
| NCBI Full Name: | Gamma-tubulin complex component 6 |
| NCBI Synonym Full Names: | tubulin gamma complex associated protein 6 |
| NCBI Official Symbol: | TUBGCP6 |
| NCBI Official Synonym Symbols: | GCP6; GCP-6; MCCRP; MCCRP1; MCPHCR |
| NCBI Protein Information: | gamma-tubulin complex component 6 |
| UniProt Protein Name: | Gamma-tubulin complex component 6 |
| Protein Family: | Gamma-tubulin complex component |
| UniProt Gene Name: | TUBGCP6 |
| UniProt Entry Name: | GCP6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TUBGCP6 antibody (CAB15921) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat testis using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat testis using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (20x lens). |
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