Cell Biology Antibodies 13
Anti-TUB Antibody (CAB17545)
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- SKU:
- CAB17545
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TUB Antibody |
| Antibody SKU: | CAB17545 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-230 of human TUB (NP_003311.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | U-87MG, U-251MG, PC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-230 of human TUB (NP_003311.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSSS GSTS YQVQ EADS LASV QLGA TRPT APAS AKRT KAAA TAGG QGGA ARKE KKGK HKGT SGPA ALAE DKSE AQGP VQIL TVGQ SDHA QDAG ETAA GGGE R |
| Gene ID: | 7275 |
| Uniprot: | P50607 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 56kDa |
 | Western blot - TUB Polyclonal Antibody (CAB17545) |
| Synonyms: | RDOB, rd5, TUB |
| Background: | This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. |
| NCBI Summary: | This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50607 |
| NCBI GenInfo Identifier: | 19923167 |
| NCBI Gene ID: | 7275 |
| NCBI Accession: | NP_003311.2 |
| UniProt Secondary Accession: | P50607,O00293, Q6B007, D3DQU4, |
| UniProt Related Accession: | P50607 |
| Molecular Weight: | 62,091 Da |
| NCBI Full Name: | tubby protein homolog isoform a |
| NCBI Synonym Full Names: | tubby bipartite transcription factor |
| NCBI Official Symbol: | TUB |
| NCBI Official Synonym Symbols: | rd5; RDOB |
| NCBI Protein Information: | tubby protein homolog |
| UniProt Protein Name: | Tubby protein homolog |
| Protein Family: | Tubby protein |
| UniProt Gene Name: | TUB |
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