Signal Transduction Antibodies 3

Anti-TTPA Antibody (CAB8562)

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SKU:
CAB8562
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-TTPA Antibody
Antibody SKU:CAB8562
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-278 of human TTPA (NP_000361.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, HepG2, DU145
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-278 of human TTPA (NP_000361.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FLLR FLRA RDFD LDLA WRLL KNYY KWRA ECPE ISAD LHPR SIIG LLKA GYHG VLRS RDPT GSKV LIYR IAHW DPKV FTAY DVFR VSLI TSEL IVQE VETQ RNGI KAIF DLEG WQFS HAFQ ITPS VAKK IAAV LTDS FPLK VRGI HLIN EPVI FHAV FSMI KPFL TEKI KERI HMHG NNYK QSLL QHFP DILP LEYG GEEF SMED ICQE WTNF IMKS EDYL SSIS ESIQ
Gene ID:7274
Uniprot:P49638
Cellular Location:Cytoplasm
Calculated MW:31kDa
Observed MW:37kDa
Synonyms:TTPA, ATTP, AVED, TTP1, alphaTTP
Background:This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
UniProt Protein Function:TTPA: Binds alpha-tocopherol and enhances its transfer between separate membranes. Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED). AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E.
UniProt Protein Details:

Protein type:Lipid-binding

Chromosomal Location of Human Ortholog: 8q12.3

Molecular Function:phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; vitamin E binding

Biological Process: intermembrane transport; lipid metabolic process; transport; vitamin transport

Disease: Vitamin E, Familial Isolated Deficiency Of

NCBI Summary:This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
UniProt Code:P49638
NCBI GenInfo Identifier:1351322
NCBI Gene ID:7274
NCBI Accession:P49638.1
UniProt Secondary Accession:P49638,Q71V64,
UniProt Related Accession:P49638
Molecular Weight:32kDa
NCBI Full Name:Alpha-tocopherol transfer protein
NCBI Synonym Full Names:alpha tocopherol transfer protein
NCBI Official Symbol:TTPA  
NCBI Official Synonym Symbols:ATTP; AVED; TTP1; alphaTTP  
NCBI Protein Information:alpha-tocopherol transfer protein
UniProt Protein Name:Alpha-tocopherol transfer protein
Protein Family:Alpha-tocopherol transfer protein
UniProt Gene Name:TTPA  
Anti-TTPA Polyclonal Antibody (CAB8562)Western blot analysis of extracts of various cell lines, using TTPA antibody (CAB8562) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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