Cell Biology Antibodies 14
Anti-TTF1 Antibody (CAB18128)
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- SKU:
- CAB18128
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TTF1 Antibody |
| Antibody SKU: | CAB18128 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TTF1. |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TTF1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7270 |
| Uniprot: | Q15361 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
 | Immunofluorescence - TTF1 Rabbit pAb (CAB18128) |
| Synonyms: | TTF-1, TTF-I, TTF1 |
| Background: | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
| UniProt Protein Function: | TTF1: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding Chromosomal Location of Human Ortholog: 9q34.13 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:chromatin binding; DNA binding Biological Process: cellular protein metabolic process; chromatin remodeling; gene expression; negative regulation of DNA replication; negative regulation of gene expression, epigenetic; regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; transcription termination |
| NCBI Summary: | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q15361 |
| NCBI GenInfo Identifier: | 328927005 |
| NCBI Gene ID: | 7270 |
| NCBI Accession: | NP_001192225.1 |
| UniProt Secondary Accession: | Q15361,Q4VXF3, Q58EY2, Q6P5T5, A1L160, |
| UniProt Related Accession: | Q15361 |
| Molecular Weight: | 103,051 Da |
| NCBI Full Name: | transcription termination factor 1 isoform 2 |
| NCBI Synonym Full Names: | transcription termination factor, RNA polymerase I |
| NCBI Official Symbol: | TTF1 |
| NCBI Official Synonym Symbols: | TTF-1; TTF-I |
| NCBI Protein Information: | transcription termination factor 1 |
| UniProt Protein Name: | Transcription termination factor 1 |
| UniProt Synonym Protein Names: | RNA polymerase I termination factor; Transcription termination factor I; TTF-I |
| Protein Family: | Transcription termination factor |
| UniProt Gene Name: | TTF1 |
| UniProt Entry Name: | TTF1_HUMAN |
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