Epigenetics & Nuclear Signaling Antibodies 1
Anti-TTC5 Antibody (CAB13232)
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- SKU:
- CAB13232
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-TTC5 Antibody |
| Antibody SKU: | CAB13232 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TTC5 (NP_612385.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, MCF7, Mouse spleen, Mouse testis, Mouse thymus, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TTC5 (NP_612385.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMAD EEEE VKPI LQKL QELV DQLY SFRD CYFE THSV EDAG RKQQ DVQK EMEK TLQQ MEEV VGSV QGKA QVLM LTGK ALNV TPDY SPKA EELL SKAV KLEP ELVE AWNQ LGEV YWKK GDVA AAHT CFSG ALTH CRNK VSLQ NLSM VLRQ LRTD TEDE HSHH VMDS VRQA KLAV QMDV HDGR SWYI LGNS YLSL YFST GQNP KISQ QALS AYAQ AEKV DRKA SSNP DLHL NRAT LHKY EESY GEAL EGFS RAAA LDPA WPEP RQRE QQLL EFLD RLTS LLES KGKV KTKK LQSM LGSL RPAH |
| Gene ID: | 91875 |
| Uniprot: | Q8N0Z6 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 48kDa |
| Observed MW: | 49kDa |
| Synonyms: | TTC5, Strap |
| Background: |
| UniProt Protein Function: | TTC5: Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; cytoplasm Molecular Function:DNA binding; chromatin binding Biological Process: positive regulation of transcription from RNA polymerase II promoter; DNA repair |
| UniProt Code: | Q8N0Z6 |
| NCBI GenInfo Identifier: | 67462006 |
| NCBI Gene ID: | |
| NCBI Accession: | Q8N0Z6.1 |
| UniProt Secondary Accession: | Q8N0Z6,Q99LG4, Q5BK48, |
| Molecular Weight: | 48,928 Da |
| NCBI Full Name: | Tetratricopeptide repeat protein 5 |
| UniProt Protein Name: | Tetratricopeptide repeat protein 5 |
| UniProt Synonym Protein Names: | Stress-responsive activator of p300; Strap |
| Protein Family: | Tetratricopeptide repeat protein |
| UniProt Gene Name: | TTC5 |
| UniProt Entry Name: | TTC5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TTC5 antibody (CAB13232) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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