Cell Cycle Antibodies 1
Anti-TSPYL2 Antibody (CAB13118)
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- SKU:
- CAB13118
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-TSPYL2 Antibody |
| Antibody SKU: | CAB13118 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-460 of human TSPYL2 (NP_071400.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Mouse brain, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-460 of human TSPYL2 (NP_071400.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKRK FIQM RRPF LERR DLII QHIP GFWV KAFL NHPR ISIL INRR DEDI FRYL TNLQ VQDL RHIS MGYK MKLY FQTN PYFT NMVI VKEF QRNR SGRL VSHS TPIR WHRG QEPQ ARRH GNQD ASHS FFSW FSNH SLPE ADRI AEII KNDL WVNP LRYY LRER GSRI KRKK QEMK KRKT RGRC EVVI MEDA PDYY AVED IFSE ISDI DETI HDIK ISDF METT D |
| Gene ID: | 64061 |
| Uniprot: | Q9H2G4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 79kDa |
| Observed MW: | 110kDa |
| Synonyms: | TSPYL2, CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX |
| Background: | This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. |
| UniProt Protein Function: | TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family. |
| UniProt Protein Details: | Protein type:Transcription regulation; DNA replication Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: centrosome; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Biological Process: negative regulation of cell growth; negative regulation of DNA replication; regulation of protein kinase activity |
| NCBI Summary: | This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9H2G4 |
| NCBI GenInfo Identifier: | 74752604 |
| NCBI Gene ID: | 64061 |
| NCBI Accession: | Q9H2G4.1 |
| UniProt Secondary Accession: | Q9H2G4,O94799, Q96DG7, Q9BZW6, |
| UniProt Related Accession: | Q9H2G4 |
| Molecular Weight: | 79,435 Da |
| NCBI Full Name: | Testis-specific Y-encoded-like protein 2 |
| NCBI Synonym Full Names: | TSPY like 2 |
| NCBI Official Symbol: | TSPYL2 |
| NCBI Official Synonym Symbols: | CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216 |
| NCBI Protein Information: | testis-specific Y-encoded-like protein 2 |
| UniProt Protein Name: | Testis-specific Y-encoded-like protein 2 |
| UniProt Synonym Protein Names: | Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79 |
| Protein Family: | Testis-specific Y-encoded-like protein |
| UniProt Gene Name: | TSPYL2 |
| UniProt Entry Name: | TSYL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TSPYL2 antibody (CAB13118) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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