Immunology Antibodies 1
Anti-TSPAN7 Antibody (CAB13555)
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- SKU:
- CAB13555
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TSPAN7 Antibody |
| Antibody SKU: | CAB13555 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 113-213 of human TSPAN7 (NP_004606.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 113-213 of human TSPAN7 (NP_004606.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RHEI KDTF LRTY TDAM QTYN GNDE RSRA VDHV QRSL SCCG VQNY TNWS TSPY FLEH GIPP SCCM NETD CNPQ DLHN LTVA ATKV NQKG CYDL VTSF METN M |
| Gene ID: | 7102 |
| Uniprot: | P41732 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 27kDa |
| Observed MW: | 35KDa |
| Synonyms: | TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. |
| UniProt Protein Function: | TSPAN7: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Defects in TSPAN7 are the cause of mental retardation X- linked type 58 (MRX58). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: integral to plasma membrane Biological Process: viral reproduction Disease: Mental Retardation, X-linked 58 |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41732 |
| NCBI GenInfo Identifier: | 17380550 |
| NCBI Gene ID: | 7102 |
| NCBI Accession: | P41732.2 |
| UniProt Secondary Accession: | P41732,Q8WVG5, Q9UEY9, B2R5W7, D3DWB1, |
| UniProt Related Accession: | P41732 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Tetraspanin-7 |
| NCBI Synonym Full Names: | tetraspanin 7 |
| NCBI Official Symbol: | TSPAN7 |
| NCBI Official Synonym Symbols: | A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E |
| NCBI Protein Information: | tetraspanin-7; tspan-7; CD231 antigen; tetraspanin protein; transmembrane protein A15; cell surface glycoprotein A15; transmembrane 4 superfamily 2b; transmembrane 4 superfamily member 2; membrane component chromosome X surface marker 1; membrane component, X chromosome, surface marker 1; T-cell acute lymphoblastic leukemia associated antigen 1; T-cell acute lymphoblastic leukemia-associated antigen 1 |
| UniProt Protein Name: | Tetraspanin-7 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein A15; Membrane component chromosome X surface marker 1; T-cell acute lymphoblastic leukemia-associated antigen 1; TALLA-1; Transmembrane 4 superfamily member 2; CD_antigen: CD231 |
| UniProt Gene Name: | TSPAN7 |
| UniProt Entry Name: | TSN7_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using TSPAN7 antibody (CAB13555) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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