Immunology Antibodies 1
Anti-TSPAN7 Antibody (CAB13554)
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- SKU:
- CAB13554
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TSPAN7 Antibody |
| Antibody SKU: | CAB13554 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-249 of human TSPAN7 (NP_004606.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-249 of human TSPAN7 (NP_004606.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FVFR HEIK DTFL RTYT DAMQ TYNG NDER SRAV DHVQ RSLS CCGV QNYT NWST SPYF LEHG IPPS CCMN ETDC NPQD LHNL TVAA TKVN QKGC YDLV TSFM ETNM GIIA GVAF GIAF SQLI GMLL ACCL SRFI TANQ YEMV |
| Gene ID: | 7102 |
| Uniprot: | P41732 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 27kDa |
| Observed MW: |
| Synonyms: | TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. |
| UniProt Protein Function: | TSPAN7: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Defects in TSPAN7 are the cause of mental retardation X- linked type 58 (MRX58). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: integral to plasma membrane Biological Process: viral reproduction Disease: Mental Retardation, X-linked 58 |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41732 |
| NCBI GenInfo Identifier: | 17380550 |
| NCBI Gene ID: | 7102 |
| NCBI Accession: | P41732.2 |
| UniProt Secondary Accession: | P41732,Q8WVG5, Q9UEY9, B2R5W7, D3DWB1, |
| UniProt Related Accession: | P41732 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Tetraspanin-7 |
| NCBI Synonym Full Names: | tetraspanin 7 |
| NCBI Official Symbol: | TSPAN7 |
| NCBI Official Synonym Symbols: | A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E |
| NCBI Protein Information: | tetraspanin-7; tspan-7; CD231 antigen; tetraspanin protein; transmembrane protein A15; cell surface glycoprotein A15; transmembrane 4 superfamily 2b; transmembrane 4 superfamily member 2; membrane component chromosome X surface marker 1; membrane component, X chromosome, surface marker 1; T-cell acute lymphoblastic leukemia associated antigen 1; T-cell acute lymphoblastic leukemia-associated antigen 1 |
| UniProt Protein Name: | Tetraspanin-7 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein A15; Membrane component chromosome X surface marker 1; T-cell acute lymphoblastic leukemia-associated antigen 1; TALLA-1; Transmembrane 4 superfamily member 2; CD_antigen: CD231 |
| UniProt Gene Name: | TSPAN7 |
| UniProt Entry Name: | TSN7_HUMAN |
 | Immunofluorescence analysis of U2OS cells using TSPAN7 antibody (CAB13554). Blue: DAPI for nuclear staining. |
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