Cell Biology Antibodies 13

Anti-TSPAN6 Antibody (CAB17540)

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SKU:
CAB17540
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TSPAN6 Antibody
Antibody SKU:CAB17540
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human TSPAN6 (NP_003261.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human TSPAN6 (NP_003261.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NSFK NNYE KALK QYNS TGDY RSHA VDKI QNTL HCCG VTDY RDWT DTNY YSEK GFPK SCCK LEDC TPQR DADK VNNE GCFI K
Gene ID:7105
Uniprot:O43657
Cellular Location:
Calculated MW:
Observed MW:28kDa
Anti-TSPAN6 Antibody (CAB17540)Western blot - TSPAN6 Polyclonal Antibody (CAB17540)
Synonyms:T245, TM4SF6, TSPAN-6, TSPAN6
Background:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
UniProt Protein Function:TSPAN6: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: integral to plasma membrane

Molecular Function:protein binding; signal transducer activity

Biological Process: cell surface receptor linked signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade

NCBI Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
UniProt Code:O43657
NCBI GenInfo Identifier:11135101
NCBI Gene ID:7105
NCBI Accession:O43657.1
UniProt Secondary Accession:O43657,Q54A42, Q6IAN9,
UniProt Related Accession:O43657
Molecular Weight:27,563 Da
NCBI Full Name:Tetraspanin-6
NCBI Synonym Full Names:tetraspanin 6
NCBI Official Symbol:TSPAN6  
NCBI Official Synonym Symbols:T245; TM4SF6; TSPAN-6  
NCBI Protein Information:tetraspanin-6
UniProt Protein Name:Tetraspanin-6
UniProt Synonym Protein Names:A15 homolog; Putative NF-kappa-B-activating protein 321; T245 protein; Tetraspanin TM4-D; Transmembrane 4 superfamily member 6
UniProt Gene Name:TSPAN6  
UniProt Entry Name:TSN6_HUMAN
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