Cell Biology Antibodies 1

Anti-TSPAN4 Antibody (CAB10253)

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SKU:
CAB10253
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TSPAN4 Antibody
Antibody SKU:CAB10253
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 107-201 of human TSPAN4 (NP_003262.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Mouse kidney, Mouse lung, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 107-201 of human TSPAN4 (NP_003262.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YTDK IDRY AQQD LKKG LHLY GTQG NVGL TNAW SIIQ TDFR CCGV SNYT DWFE VYNA TRVP DSCC LEFS ESCG LHAP GTWW KAPC YETV KVWL QEN
Gene ID:7106
Uniprot:O14817
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:26kDa
Observed MW:26kDa
Synonyms:TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4
Background:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:TSPAN4: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane; vesicle

Molecular Function:antigen binding; integrin binding; protein binding

Biological Process: cell surface receptor linked signal transduction; protein complex assembly

NCBI Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:O14817
NCBI GenInfo Identifier:3183082
NCBI Gene ID:7106
NCBI Accession:O14817.1
UniProt Secondary Accession:O14817,Q6IAP6,
UniProt Related Accession:O14817
Molecular Weight:26kDa
NCBI Full Name:Tetraspanin-4
NCBI Synonym Full Names:tetraspanin 4
NCBI Official Symbol:TSPAN4  
NCBI Official Synonym Symbols:NAG2; NAG-2; TM4SF7; TSPAN-4; TETRASPAN  
NCBI Protein Information:tetraspanin-4
UniProt Protein Name:Tetraspanin-4
UniProt Synonym Protein Names:Novel antigen 2; NAG-2; Transmembrane 4 superfamily member 7
UniProt Gene Name:TSPAN4  
Anti-TSPAN4 Antibody (CAB10253)Western blot analysis of extracts of various cell lines, using TSPAN4 antibody (CAB10253) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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