Cell Biology Antibodies 5
Anti-TSPAN3 Antibody (CAB14833)
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- SKU:
- CAB14833
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TSPAN3 Antibody |
| Antibody SKU: | CAB14833 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-210 of human TSPAN3 (NP_005715.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 105-210 of human TSPAN3 (NP_005715.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YVYR AKVE NEVD RSIQ KVYK TYNG TNPD AASR AIDY VQRQ LHCC GIHN YSDW ENTD WFKE TKNQ SVPL SCCR ETAS NCNG SLAH PSDL YAEG CEAL VVKK LQEI MM |
| Gene ID: | 10099 |
| Uniprot: | O60637 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 21kDa/25kDa/28kDa |
| Observed MW: | 28kDa |
| Synonyms: | TSPAN3, TM4-A, TM4SF8, TSPAN-3 |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. |
| UniProt Protein Function: | TSPAN3: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 15q24.3 Cellular Component: integral to membrane |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009] |
| UniProt Code: | O60637 |
| NCBI GenInfo Identifier: | 15029948 |
| NCBI Gene ID: | 10099 |
| NCBI Accession: | AAH11206.1 |
| UniProt Secondary Accession: | O60637,Q9BW22, Q9NVX9, A6NEH4, B3KQQ2, B4DP19, |
| UniProt Related Accession: | O60637 |
| Molecular Weight: | 25 kDa (MW of target protein) |
| NCBI Full Name: | Tetraspanin 3 |
| NCBI Synonym Full Names: | tetraspanin 3 |
| NCBI Official Symbol: | TSPAN3 |
| NCBI Official Synonym Symbols: | TM4-A; TM4SF8; TSPAN-3 |
| NCBI Protein Information: | tetraspanin-3 |
| UniProt Protein Name: | Tetraspanin-3 |
| UniProt Synonym Protein Names: | Tetraspanin TM4-A; Transmembrane 4 superfamily member 8 |
| UniProt Gene Name: | TSPAN3 |
| UniProt Entry Name: | TSN3_HUMAN |
 | Western blot analysis of extracts of mouse small intestine, using TSPAN3 antibody (CAB14833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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