Cell Biology Antibodies 15
Anti-TSN Antibody (CAB18590)
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- SKU:
- CAB18590
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TSN Antibody |
| Antibody SKU: | CAB18590 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TSN (NP_004613.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, HeLa, Mouse spleen, Mouse brain, Rat thymus, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TSN (NP_004613.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7247 |
| Uniprot: | Q15631 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 17kDa/26kDa |
| Observed MW: | 26kDa |
 | Western blot - TSN Rabbit pAb (CAB18590) |
| Synonyms: | BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, TSN, translin |
| Background: | This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TSN: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Belongs to the translin family. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor co-regulator; EC 3.1.-.- Chromosomal Location of Human Ortholog: 2q21.1 Cellular Component: cytosol Molecular Function:DNA binding; protein binding Biological Process: DNA recombination; RNA-mediated gene silencing |
| NCBI Summary: | This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] |
| UniProt Code: | Q15631 |
| NCBI GenInfo Identifier: | 6136060 |
| NCBI Gene ID: | 7247 |
| NCBI Accession: | Q15631.1 |
| UniProt Secondary Accession: | Q15631,Q5U0K7, B7Z3X8, |
| UniProt Related Accession: | Q15631 |
| Molecular Weight: | 17,279 Da |
| NCBI Full Name: | Translin |
| NCBI Synonym Full Names: | translin |
| NCBI Official Symbol: | TSN |
| NCBI Official Synonym Symbols: | C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1 |
| NCBI Protein Information: | translin |
| UniProt Protein Name: | Translin |
| UniProt Synonym Protein Names: | Component 3 of promoter of RISC; C3PO |
| Protein Family: | Translin |
| UniProt Gene Name: | TSN |
| UniProt Entry Name: | TSN_HUMAN |
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