Immunology Antibodies 1
Anti-TSLP Antibody (CAB13134)
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- SKU:
- CAB13134
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TSLP Antibody |
| Antibody SKU: | CAB13134 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-159 of human TSLP (NP_149024.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-159 of human TSLP (NP_149024.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YDFT NCDF EKIK AAYL STIS KDLI TYMS GTKS TEFN NTVS CSNR PHCL TEIQ SLTF NPTA GCAS LAKE MFAM KTKA ALAI WCPG YSET QINA TQAM KKRR KRKV TTNK CLEQ VSQL QGLW RRFN RPLL KQQ |
| Gene ID: | 85480 |
| Uniprot: | Q969D9 |
| Cellular Location: | Secreted |
| Calculated MW: | 7kDa/18kDa |
| Observed MW: | 18kDa |
| Synonyms: | TSLP |
| Background: | This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q22.1 Cellular Component: extracellular space Molecular Function:cytokine activity |
| NCBI Summary: | This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q969D9 |
| NCBI GenInfo Identifier: | 74751719 |
| NCBI Gene ID: | 85480 |
| NCBI Accession: | Q969D9.1 |
| UniProt Secondary Accession: | Q969D9,Q8IW99, Q96AU7, G3XAM8, |
| UniProt Related Accession: | Q969D9 |
| Molecular Weight: | 7,426 Da |
| NCBI Full Name: | Thymic stromal lymphopoietin |
| NCBI Synonym Full Names: | thymic stromal lymphopoietin |
| NCBI Official Symbol: | TSLP |
| NCBI Protein Information: | thymic stromal lymphopoietin |
| UniProt Protein Name: | Thymic stromal lymphopoietin |
| Protein Family: | Thymic stromal lymphopoietin |
| UniProt Gene Name: | TSLP |
| UniProt Entry Name: | TSLP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TSLP antibody (CAB13134) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using TSLP antibody (CAB13134) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using TSLP antibody (CAB13134) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using TSLP antibody (CAB13134) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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