Antibody Name:	Anti-TSHB Antibody
Antibody SKU:	CAB6780
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-138 of human TSHB (NP_000540.2).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-138 of human TSHB (NP_000540.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	FCIP TEYT MHIE RREC AYCL TINT TICA GYCM TRDI NGKL FLPK YALS QDVC TYRD FIYR TVEI PGCP LHVA PYFS YPVA LSCK CGKC NTDY SDCI HEAI KTNY CTKP QKSY LVGF SV
Gene ID:	7252
Uniprot:	P01222
Cellular Location:	Secreted
Calculated MW:	10kDa/15kDa
Observed MW:	Refer to Figures

Synonyms:

TSHB, TSH-B, TSH-BETA

Background:

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.

UniProt Protein Function:	TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p13 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A Disease: Hypothyroidism, Congenital, Nongoitrous, 4
NCBI Summary:	The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:	P01222
NCBI GenInfo Identifier:	311033515
NCBI Gene ID:	7252
NCBI Accession:	P01222.2
UniProt Secondary Accession:	P01222,Q16163, B1AKP0,
UniProt Related Accession:	P01222
Molecular Weight:	138
NCBI Full Name:	Thyrotropin subunit beta
NCBI Synonym Full Names:	thyroid stimulating hormone, beta
NCBI Official Symbol:	TSHB
NCBI Official Synonym Symbols:	TSH-B; TSH-BETA
NCBI Protein Information:	thyrotropin subunit beta; thyrotropin beta chain
UniProt Protein Name:	Thyrotropin subunit beta
UniProt Synonym Protein Names:	Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa
Protein Family:	Thyrotropin
UniProt Gene Name:	TSHB
UniProt Entry Name:	TSHB_HUMAN

	Immunohistochemistry of paraffin-embedded human prostate using TSHB antibody (CAB6780) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse lung using TSHB antibody (CAB6780) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of U2OS cells using TSHB antibody (CAB6780). Blue: DAPI for nuclear staining.