Cell Biology Antibodies 5

Anti-TSHB Antibody (CAB14523)

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SKU:
CAB14523
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TSHB Antibody
Antibody SKU:CAB14523
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TSHB (NP_000540.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, LO2, Mouse liver, Mouse kidney, Mouse brain, Rat liver, Rat kidney, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TSHB (NP_000540.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YCMT RDIN GKLF LPKY ALSQ DVCT YRDF IYRT VEIP GCPL HVAP YFSY PVAL SCKC GKCN TDYS DCIH EAIK TNYC TKPQ KSYL VGFS V
Gene ID:7252
Uniprot:P01222
Cellular Location:Secreted
Calculated MW:10kDa/15kDa
Observed MW:16kDa
Synonyms:TSHB, TSH-B, TSH-BETA
Background:The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: extracellular region

Molecular Function:hormone activity

Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A

Disease: Hypothyroidism, Congenital, Nongoitrous, 4

NCBI Summary:The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:P01222
NCBI GenInfo Identifier:311033515
NCBI Gene ID:7252
NCBI Accession:P01222.2
UniProt Secondary Accession:P01222,Q16163, B1AKP0,
UniProt Related Accession:P01222
Molecular Weight:138
NCBI Full Name:Thyrotropin subunit beta
NCBI Synonym Full Names:thyroid stimulating hormone, beta
NCBI Official Symbol:TSHB  
NCBI Official Synonym Symbols:TSH-B; TSH-BETA  
NCBI Protein Information:thyrotropin subunit beta; thyrotropin beta chain
UniProt Protein Name:Thyrotropin subunit beta
UniProt Synonym Protein Names:Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa
Protein Family:Thyrotropin
UniProt Gene Name:TSHB  
UniProt Entry Name:TSHB_HUMAN
Anti-TSHB Antibody (CAB14523)Western blot analysis of extracts of various cell lines, using TSHB antibody (CAB14523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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