Cell Biology Antibodies 6

Anti-TRPV6 Antibody (CAB16128)

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SKU:
CAB16128
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TRPV6 Antibody
Antibody SKU:CAB16128
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRPV6 (NP_061116.5).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HT-29, BxPC-3, DU145, HepG2, Mouse pancreas
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRPV6 (NP_061116.5).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGPL QGDG GPAL GGAD VAPR LSPV RVWP RPQA PKEP ALHP MGLS LPKE KGLI LCLW SKFC RWFQ RRES WAQS RDEQ NLLQ QKRI WESP LLLA AKDN DVQA
Gene ID:55503
Uniprot:Q9H1D0
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:68kDa/87kDa
Observed MW:87kDa
Synonyms:TRPV6, ABP/ZF, CAT1, CATL, ECAC2, HSA277909, LP6728, ZFAB
Background:This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds.
UniProt Protein Function:TRPV6: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:calmodulin binding; protein binding; calcium channel activity

Biological Process: calcium ion transport; transmembrane transport; regulation of calcium ion-dependent exocytosis

UniProt Code:Q9H1D0
NCBI GenInfo Identifier:62901469
NCBI Gene ID:
NCBI Accession:Q9H1D0.2
Molecular Weight:87kDa
NCBI Full Name:Transient receptor potential cation channel subfamily V member 6
UniProt Protein Name:Transient receptor potential cation channel subfamily V member 6
UniProt Synonym Protein Names:CaT-like; CaT-L; Calcium transport protein 1; CaT1; Epithelial calcium channel 2; ECaC2
Protein Family:Transient receptor potential cation channel subfamily
UniProt Gene Name:TRPV6  
UniProt Entry Name:TRPV6_HUMAN
Anti-TRPV6 Antibody (CAB16128)Western blot analysis of extracts of various cell lines, using TRPV6 antibody (CAB16128) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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