Cell Biology Antibodies 9
Anti-TRPV4 Antibody (CAB5660)
- SKU:
- CAB5660
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRPV4 Antibody |
| Antibody SKU: | CAB5660 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TRPV4 (NP_067638.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TRPV4 (NP_067638.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GKNE TYQY YGFS HTVG RLRR DRWS SVVP RVVE LNKN SNPD EVVV PLDS MGNP RCDG HQQG YPRK WRTD DAPL |
| Gene ID: | 59341 |
| Uniprot: | Q9HBA0 |
| Cellular Location: | Apical cell membrane, Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, adherens junction, cilium |
| Calculated MW: | 85kDa/91kDa/92kDa/94kDa/96kDa/98kDa |
| Observed MW: | 95KDa |
| Synonyms: | TRPV4, BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC |
| Background: | This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, cation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: cortical actin cytoskeleton; cell surface; focal adhesion; adherens junction; growth cone; lamellipodium; cytoplasmic microtubule; integral to membrane; plasma membrane; cytoplasmic vesicle; filopodium; cilium Molecular Function:microtubule binding; calcium channel activity; beta-tubulin binding; actin binding; protein kinase binding; actin filament binding; calmodulin binding; protein binding; protein kinase C binding; osmosensor activity; cation channel activity; SH2 domain binding; alpha-tubulin binding; ATP binding Biological Process: intercellular junction assembly; actin filament organization; regulation of response to osmotic stress; cellular calcium ion homeostasis; osmosensory signaling pathway; vasopressin secretion; elevation of cytosolic calcium ion concentration; positive regulation of microtubule depolymerization; hyperosmotic salinity response; response to mechanical stimulus; calcium ion transport; actin cytoskeleton reorganization; cell volume homeostasis; cortical microtubule organization and biogenesis; transmembrane transport; microtubule polymerization Disease: Brachyolmia Type 3; Scapuloperoneal Spinal Muscular Atrophy; Hereditary Motor And Sensory Neuropathy, Type Iic; Sodium Serum Level Quantitative Trait Locus 1; Spondyloepiphyseal Dysplasia, Maroteaux Type; Parastremmatic Dwarfism; Spinal Muscular Atrophy, Distal, Congenital Nonprogressive; Digital Arthropathy-brachydactyly, Familial; Metatropic Dysplasia; Spondylometaphyseal Dysplasia, Kozlowski Type |
| NCBI Summary: | This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] |
| UniProt Code: | Q9HBA0 |
| NCBI GenInfo Identifier: | 62901470 |
| NCBI Gene ID: | 59341 |
| NCBI Accession: | Q9HBA0.2 |
| UniProt Secondary Accession: | Q9HBA0,Q17R79, Q2Y122, Q2Y123, Q2Y124, Q86YZ6, Q8NDY7 Q8NG64, Q96Q92, Q96RS7, Q9HBC0, B7ZKQ6, |
| UniProt Related Accession: | Q9HBA0 |
| Molecular Weight: | 871 |
| NCBI Full Name: | Transient receptor potential cation channel subfamily V member 4 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily V, member 4 |
| NCBI Official Symbol: | TRPV4 |
| NCBI Official Synonym Symbols: | SMAL; VRL2; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily V member 4; osm-9-like TRP channel 4; vanilloid receptor-like channel 2; transient receptor potential protein 12; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; vanilloid receptor-related osmotically activated channel |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily V member 4 |
| UniProt Synonym Protein Names: | Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPV4 |
| UniProt Entry Name: | TRPV4_HUMAN |
 | Western blot analysis of extracts of Mouse heart, using TRPV4 antibody (CAB5660) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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