Cell Biology Antibodies 2

Anti-TRPV2 Antibody (CAB12367)

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SKU:
CAB12367
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TRPV2 Antibody
Antibody SKU:CAB12367
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 655-764 of human TRPV2 (NP_057197.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A375, SKOV3, 22Rv1, BxPC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 655-764 of human TRPV2 (NP_057197.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DSWS IWKL QKAI SVLE MENG YWWC RKKQ RAGV MLTV GTKP DGSP DERW CFRV EEVN WASW EQTL PTLC EDPS GAGV PRTL ENPV LASP PKED EDGA SEEN YVPV QLLQ SN
Gene ID:51393
Uniprot:Q9Y5S1
Cellular Location:Cell membrane, Cytoplasm, Melanosome, Multi-pass membrane protein
Calculated MW:85kDa
Observed MW:86kDa
Synonyms:TRPV2, VRL, VRL-1, VRL1
Background:This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
UniProt Protein Function:TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; melanosome; endomembrane system

Molecular Function:calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity

Biological Process: response to temperature stimulus; transport; response to heat; positive regulation of axon extension; sensory perception; transmembrane transport

NCBI Summary:This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5S1
NCBI GenInfo Identifier:62901477
NCBI Gene ID:51393
NCBI Accession:Q9Y5S1.1
UniProt Secondary Accession:Q9Y5S1,Q9Y670, A6NML2, A8K0Z0,
UniProt Related Accession:Q9Y5S1
Molecular Weight:85,981 Da
NCBI Full Name:Transient receptor potential cation channel subfamily V member 2
NCBI Synonym Full Names:transient receptor potential cation channel, subfamily V, member 2
NCBI Official Symbol:TRPV2  
NCBI Official Synonym Symbols:VRL; VRL1; VRL-1  
NCBI Protein Information:transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1
UniProt Protein Name:Transient receptor potential cation channel subfamily V member 2
UniProt Synonym Protein Names:Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1
Protein Family:Transient receptor potential cation channel subfamily
UniProt Gene Name:TRPV2  
UniProt Entry Name:TRPV2_HUMAN
Anti-TRPV2 Antibody (CAB12367)Western blot analysis of extracts of various cell lines, using TRPV2 antibody (CAB12367) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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