Cardiovascular Antibodies
Anti-TrpRS Antibody (CAB4469)
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- SKU:
- CAB4469
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-TrpRS Antibody |
| Antibody SKU: | CAB4469 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TrpRS |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse testis, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human TrpRS |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7453 |
| Uniprot: | P23381 |
| Cellular Location: | |
| Calculated MW: | 53kDa |
| Observed MW: | 53KDa |
| Synonyms: | GAMMA-2, IFI53, IFP53 |
| Background: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation; Amino Acid Metabolism - tryptophan; Ligase; EC 6.1.1.2 Chromosomal Location of Human Ortholog: 14q32.31 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:protein binding; tryptophan-tRNA ligase activity; ATP binding Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation; translation; gene expression; angiogenesis; regulation of angiogenesis |
| NCBI Summary: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P23381 |
| NCBI GenInfo Identifier: | 135191 |
| NCBI Gene ID: | 7453 |
| NCBI Accession: | P23381.2 |
| UniProt Secondary Accession: | P23381,P78535, Q502Y0, Q53XB6, Q9UDI5, Q9UDL3, A6NGN1 A6NID3, |
| UniProt Related Accession: | P23381 |
| Molecular Weight: | 471 |
| NCBI Full Name: | Tryptophan--tRNA ligase, cytoplasmic |
| NCBI Synonym Full Names: | tryptophanyl-tRNA synthetase |
| NCBI Official Symbol: | WARS |
| NCBI Official Synonym Symbols: | IFI53; IFP53; GAMMA-2 |
| NCBI Protein Information: | tryptophan--tRNA ligase, cytoplasmic; hWRS; trpRS; interferon-induced protein 53; tryptophan tRNA ligase 1, cytoplasmic |
| UniProt Protein Name: | Tryptophan--tRNA ligase, cytoplasmic |
| UniProt Synonym Protein Names: | Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS |
| Protein Family: | Tryptophan--tRNA ligase |
| UniProt Gene Name: | WARS |
| UniProt Entry Name: | SYWC_HUMAN |
 | Western blot - TrpRS Rabbit mAb (CAB4469) |
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