Cell Biology Antibodies 11
Anti-TRPC6 Antibody (CAB8155)
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- SKU:
- CAB8155
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | TRPC6 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8155 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TRPC6 (NP_004612.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, mouse lung, mouse brain, rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TRPC6 (NP_004612.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SWVI GMIW AECK EIWT QGPK EYLF ELWN MLDF GMLA IFAA SFIA RFMA FWHA SKAQ SIID ANDT LKDL TKVT LGDN VKYY NLAR IKWD PSDP QIIS EGLY A |
| Gene ID: | 7225 |
| Uniprot: | Q9Y210 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 93kDa/100kDa/106kDa |
| Observed MW: | 106kDa |
| Synonyms: | TRPC6, FSGS2, TRP6 |
| Background: | The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). |
| UniProt Protein Function: | TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, cation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q22.1 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding; store-operated calcium channel activity Biological Process: positive regulation of ion transmembrane transporter activity; platelet activation; axon guidance; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging Disease: Focal Segmental Glomerulosclerosis 2 |
| NCBI Summary: | The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9Y210 |
| NCBI GenInfo Identifier: | 6686048 |
| NCBI Gene ID: | 7225 |
| NCBI Accession: | Q9Y210.1 |
| UniProt Secondary Accession: | Q9Y210,Q52M59, Q9HCW3, Q9NQA8, Q9NQA9, |
| UniProt Related Accession: | Q9Y210 |
| Molecular Weight: | 100,106 Da |
| NCBI Full Name: | Short transient receptor potential channel 6 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily C, member 6 |
| NCBI Official Symbol: | TRPC6 |
| NCBI Official Synonym Symbols: | TRP6; FSGS2 |
| NCBI Protein Information: | short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2 |
| UniProt Protein Name: | Short transient receptor potential channel 6 |
| UniProt Synonym Protein Names: | Transient receptor protein 6; TRP-6 |
| Protein Family: | Short transient receptor potential channel |
| UniProt Gene Name: | TRPC6 |
| UniProt Entry Name: | TRPC6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRPC6 antibody (CAB8155) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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