Cell Biology Antibodies 10
Anti-TRPC4 Antibody (CAB6996)
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- SKU:
- CAB6996
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRPC4 Antibody |
| Antibody SKU: | CAB6996 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SKOV3, BT-474, HeLa, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SKES SNSA DSDE KSDS EGNS KDKK KNFS LFDL TTLI HPRS AAIA SERH NISN GSAL VVQE PPRE KQRK VNFV TDIK NFGL FHRR SKQN AAEQ NANQ IFSV SEEV ARQQ AAGP LERN IQLE SRGL ASRG DLSI PGLS EQCV LVDH RERN TDTL GLQV GKRV CPFK SEKV VVED TVPI IPKE KHAK EEDS SIDY DLNL PDTV THED YVTT RL |
| Gene ID: | 7223 |
| Uniprot: | Q9UBN4 |
| Cellular Location: | Cell membrane, Membrane, Multi-pass membrane protein |
| Calculated MW: | 36kDa/92kDa/94kDa/96kDa/102kDa/112kDa |
| Observed MW: | 112kDa |
| Synonyms: | TRPC4, HTRP-4, HTRP4, TRP4 |
| Background: | This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | TRPC4: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 13q13.3 Cellular Component: cortical cytoskeleton; cell surface; basolateral plasma membrane; plasma membrane; caveola; intercellular junction Molecular Function:protein binding; store-operated calcium channel activity; cadherin binding; beta-catenin binding Biological Process: axon guidance; calcium ion transport; gamma-aminobutyric acid secretion; oligodendrocyte differentiation; transmembrane transport |
| NCBI Summary: | This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9UBN4 |
| NCBI GenInfo Identifier: | 13633994 |
| NCBI Gene ID: | 7223 |
| NCBI Accession: | Q9UBN4.1 |
| UniProt Secondary Accession: | Q9UBN4,Q15721, Q3SWS6, Q96P03, Q96P04, Q96P05, Q9UIB0 Q9UIB1, Q9UIB2, B1ALE0, B1ALE1, B1ALE2, |
| UniProt Related Accession: | Q9UBN4 |
| Molecular Weight: | 36,759 Da |
| NCBI Full Name: | Short transient receptor potential channel 4 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily C, member 4 |
| NCBI Official Symbol: | TRPC4 |
| NCBI Official Synonym Symbols: | TRP4; HTRP4; HTRP-4 |
| NCBI Protein Information: | short transient receptor potential channel 4; trp-related protein 4 |
| UniProt Protein Name: | Short transient receptor potential channel 4 |
| UniProt Synonym Protein Names: | Trp-related protein 4; hTrp-4; hTrp4 |
| Protein Family: | Short transient receptor potential channel |
| UniProt Gene Name: | TRPC4 |
| UniProt Entry Name: | TRPC4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRPC4 antibody (CAB6996) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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