Cell Biology Antibodies 17
Anti-Troponin T Antibody (CAB4914)
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- SKU:
- CAB4914
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Troponin T Antibody |
| Antibody SKU: | CAB4914 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Troponin T |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | A synthesized peptide derived from human Troponin T |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7139 |
| Uniprot: | P45379 |
| Cellular Location: | |
| Calculated MW: | 36kDa |
| Observed MW: | 36KDa |
| Synonyms: | CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT |
| Background: | The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q32 Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament Molecular Function:troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding Biological Process: atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; metabolic process; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2 |
| NCBI Summary: | The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq] |
| UniProt Code: | P45379 |
| NCBI GenInfo Identifier: | 48255877 |
| NCBI Gene ID: | 7139 |
| NCBI Accession: | NP_000355.2 |
| UniProt Secondary Accession: | P45379,O60214, Q99596, Q99597, Q9UM96, A2TDB9, A8K3K6 |
| UniProt Related Accession: | P45379,Q15607,Q15608,Q7Z554,Q8IZA1,Q9BUF6 |
| Molecular Weight: | 35,924 Da |
| NCBI Full Name: | troponin T, cardiac muscle isoform 1 |
| NCBI Synonym Full Names: | troponin T type 2 (cardiac) |
| NCBI Official Symbol: | TNNT2 |
| NCBI Official Synonym Symbols: | CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889 |
| NCBI Protein Information: | troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant) |
| UniProt Protein Name: | Troponin T, cardiac muscle |
| UniProt Synonym Protein Names: | Cardiac muscle troponin T |
| Protein Family: | Troponin |
| UniProt Gene Name: | TNNT2 |
| UniProt Entry Name: | TNNT2_HUMAN |
 | Western blot - Troponin T Rabbit mAb (CAB4914) |
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