Anti-Troponin I1/TnI1 Antibody (CAB9664)

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SKU:
CAB9664
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SSTNI
Synonyms:
TNN1
Research Area:
Cell Biology

Description

Product Name:Troponin I1/TnI1 Rabbit mAb
Product Code:CAB9664
Size:20uL, 50uL, 100uL
Synonyms:SSTNI, TNN1
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Troponin I1/TnI1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:Rat skeletal muscle
Immunogen:A synthesized peptide derived from human Troponin I1/TnI1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7135
Uniprot:P19237
Calculated MW:22kDa
Observed MW:22KDa
UniProt Protein Function:TNNI1: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q31.3

Cellular Component: troponin complex; cytosol

Molecular Function:metal ion binding; actin binding

Biological Process: regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; muscle filament sliding

NCBI Summary:Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
UniProt Code:P19237
NCBI GenInfo Identifier:1351298
NCBI Gene ID:7135
NCBI Accession:P19237.3
UniProt Secondary Accession:P19237,Q659A5, Q6FGS7, Q6FGW1, Q6ICU2, Q86T57, Q96DT9 A6NEH3, A8MSJ0,
UniProt Related Accession:P19237
Molecular Weight:187
NCBI Full Name:Troponin I, slow skeletal muscle
NCBI Synonym Full Names:troponin I type 1 (skeletal, slow)
NCBI Official Symbol:TNNI1  
NCBI Official Synonym Symbols:TNN1; SSTNI  
NCBI Protein Information:troponin I, slow skeletal muscle; troponin I, slow-twitch isoform
UniProt Protein Name:Troponin I, slow skeletal muscle
UniProt Synonym Protein Names:Troponin I, slow-twitch isoform
Protein Family:Troponin
UniProt Gene Name:TNNI1  
UniProt Entry Name:TNNI1_HUMAN
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