Epigenetics & Nuclear Signaling Antibodies 1

Anti-TRIT1 Antibody (CAB13100)

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SKU:
CAB13100
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-TRIT1 Antibody
Antibody SKU:CAB13100
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 48-300 of human TRIT1 (NP_060116.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 48-300 of human TRIT1 (NP_060116.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GGEI VSAD SMQV YEGL DIIT NKVS AQEQ RICR HHMI SFVD PLVT NYTV VDFR NRAT ALIE DIFA RDKI PIVV GGTN YYIE SLLW KVLV NTKP QEMG TEKV IDRK VELE KEDG LVLH KRLS QVDP EMAA KLHP HDKR KVAR SLQV FEET GISH SEFL HRQH TEEG GGPL GGPL KFSN PCIL WLHA DQAV LDER LDKR VDDM LAAG LLEE LRDF HRRY NQKN VSEN SQDY QHGI FQSI GFKE FHEY LITE GKCT L
Gene ID:54802
Uniprot:Q9H3H1
Cellular Location:Cytoplasm, Mitochondrion
Calculated MW:18kDa/37kDa/43kDa/49kDa/52kDa
Observed MW:53kDa
Synonyms:TRIT1, GRO1, IPPT, IPT, IPTase, MOD5, hGRO1
Background:This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional.
UniProt Code:Q9H3H1
NCBI GenInfo Identifier:31581534
NCBI Gene ID:54802
NCBI Accession:NP_060116.2
UniProt Secondary Accession:Q9H3H1,Q3T7B5, Q5QPK5, Q5QPK6, Q6IAC9, Q96FJ3, Q96L45 Q9NXT7, A1A4X7,
UniProt Related Accession:Q9H3H1
Molecular Weight:52,725 Da
NCBI Full Name:tRNA dimethylallyltransferase, mitochondrial
NCBI Synonym Full Names:tRNA isopentenyltransferase 1
NCBI Official Symbol:TRIT1  
NCBI Official Synonym Symbols:IPT; MOD5  
NCBI Protein Information:tRNA dimethylallyltransferase, mitochondrial; IPPT; hGRO1; IPTase; IPP transferase; tRNA isopentenylpyrophosphate transferase; isopentenyl-diphosphate:tRNA isopentenyltransferase
UniProt Protein Name:tRNA dimethylallyltransferase, mitochondrial
UniProt Synonym Protein Names:Isopentenyl-diphosphate:tRNA isopentenyltransferase; IPP transferase; IPPT; hGRO1; tRNA isopentenyltransferase; IPTase
Protein Family:Cell polarity protein
UniProt Gene Name:TRIT1  
UniProt Entry Name:MOD5_HUMAN
Anti-TRIT1 Antibody (CAB13100)Western blot analysis of extracts of HeLa cells, using TRIT1 antibody (CAB13100) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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