Cell Biology Antibodies 10
Anti-TRIP10 Antibody (CAB7038)
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- SKU:
- CAB7038
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRIP10 Antibody |
| Antibody SKU: | CAB7038 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, HeLa, SKOV3, A673, 5637, Mouse kidney, Mouse heart, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AKCL EGMK VAAN AVDP KNDS HVLI ELHK SGFA RPGD VEFE DFSQ PMNR APSD SSLG TPSD GRPE LRGP GRSR TKRW PFGK KNKT VVTE DFSH LPPE QQRK RLQQ QLEE RSRE LQKE VDQR EALK KMKD VYEK TPQM GDPA SLEP QIAE TLSN IERL KLEV QKYE AWLA EAES RVLS NRGD SLSR HARP PDPP ASAP PDSS SNSA SQDT KESS EEPP SEES QDTP IYTE FDED FEEE PTSP IGHC VAIY HFEG SSEG TISM AEGE DLSL MEED KGDG WTRV RRKE GGEG YVPT SYLR VTLN |
| Gene ID: | 9322 |
| Uniprot: | Q15642 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Lysosome, cell cortex, cytoskeleton, perinuclear region, phagocytic cup |
| Calculated MW: | 39kDa/52kDa/62kDa/67kDa/68kDa |
| Observed MW: | 90kDa |
| Synonyms: | TRIP10, CIP4, HSTP, STOT, STP, TRIP-10 |
| Background: |
| UniProt Protein Function: | TRIP10: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleoplasm; Golgi apparatus; cell projection; cytoskeleton; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; cytoplasm; cell cortex; cytosol; phagocytic cup Molecular Function:identical protein binding; protein binding; lipid binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; endocytosis; cell communication; actin cytoskeleton organization and biogenesis; signal transduction |
| UniProt Code: | Q15642 |
| NCBI GenInfo Identifier: | 118572632 |
| NCBI Gene ID: | 9322 |
| NCBI Accession: | Q15642.3 |
| UniProt Related Accession: | Q15642 |
| Molecular Weight: | 39kDa; 52kDa; 62kDa; 67kDa; 68kDa |
| NCBI Full Name: | Cdc42-interacting protein 4 |
| NCBI Synonym Full Names: | thyroid hormone receptor interactor 10 |
| NCBI Official Symbol: | TRIP10 |
| NCBI Official Synonym Symbols: | STP; CIP4; HSTP; STOT; TRIP-10 |
| NCBI Protein Information: | cdc42-interacting protein 4 |
| UniProt Protein Name: | Cdc42-interacting protein 4 |
| UniProt Synonym Protein Names: | Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10 |
| Protein Family: | Cdc42-interacting protein |
| UniProt Gene Name: | TRIP10 |
| UniProt Entry Name: | CIP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRIP10 antibody (CAB7038) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using TRIP10 antibody (CAB7038). Blue: DAPI for nuclear staining. |
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