Signal Transduction Antibodies 2

Anti-TRIM41 Antibody (CAB3538)

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SKU:
CAB3538
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-TRIM41 Antibody
Antibody SKU:CAB3538
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-630 of human TRIM41 (NP_291027.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HeLa, LO2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-630 of human TRIM41 (NP_291027.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSRM FCQA ARVD LTLD PDTA HPAL MLSP DRRG VRLA ERRQ EVAD HPKR FSAD CCVL GAQG FRSG RHYW EVEV GGRR GWAV GAAR ESTH HKEK VGPG GSSV GSGD ASSS RHHH RRRR LHLP QQPL LQRE VWCV GTNG KRYQ AQSS TEQT LLSP SEKP RRFG VYLD YEAG RLGF YNAE TLAH VHTF SAAF LGER VFPF FRVL SKGT RIKL CP
Gene ID:90933
Uniprot:Q8WV44
Cellular Location:Cytoplasm, Nucleus
Calculated MW:23kDa/43kDa/59kDa/71kDa
Observed MW:72kDa
Synonyms:TRIM41, RINCK
Background:This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TRIM41: Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: nucleolus

Molecular Function:protein binding

NCBI Summary:This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q8WV44
NCBI GenInfo Identifier:116242826
NCBI Gene ID:90933
NCBI Accession:Q8WV44.3
UniProt Secondary Accession:Q8WV44,Q5BKT0, Q7L484, Q96Q10, Q9BSL8, B3KNJ6, D3DWR9
UniProt Related Accession:Q8WV44
Molecular Weight:43,491 Da
NCBI Full Name:E3 ubiquitin-protein ligase TRIM41
NCBI Synonym Full Names:tripartite motif containing 41
NCBI Official Symbol:TRIM41  
NCBI Official Synonym Symbols:RINCK  
NCBI Protein Information:E3 ubiquitin-protein ligase TRIM41
UniProt Protein Name:E3 ubiquitin-protein ligase TRIM41
UniProt Synonym Protein Names:RING finger-interacting protein with C kinase; RINCK; Tripartite motif-containing protein 41
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:TRIM41  
UniProt Entry Name:TRI41_HUMAN
Anti-TRIM41 Antibody (CAB3538)Western blot analysis of extracts of various cell lines, using TRIM41 antibody (CAB3538) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
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