Immunology Antibodies 2
Anti-TRIM4 Antibody (CAB15922)
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- SKU:
- CAB15922
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-TRIM4 Antibody |
| Antibody SKU: | CAB15922 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TRIM4 (NP_149082.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TRIM4 (NP_149082.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAE DIQE ELTC PICL DYFQ DPVS IECG HNFC RGCL HRNW APGG GPFP CPEC RHPS APAA LRPN WALA RLTE KTQR RRLG PVPP GLCG RHWE PLRL FCED DQRP VCLV CRES QEHQ THAM APID EAFE SYRE KLLK SQRN LVAK MKKV MHLQ DVEV KNAT QWKD KIKS QRMR ISTE FSKL HNFL VEEE DLFL QRLN KEEE ETKK KLNE NTLK LNQT IASL KKLI LEVG EKSQ APTL ELLQ NPKE VLTR SEIQ DVNY SLEA VKVK TVCQ IPLM KEML KRFQ |
| Gene ID: | 89122 |
| Uniprot: | Q9C037 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 34kDa/54kDa/57kDa |
| Observed MW: | 57kDa |
| Synonyms: | TRIM4, RNF87 |
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described. |
| UniProt Protein Function: | E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9C037 |
| NCBI GenInfo Identifier: | 209572691 |
| NCBI Gene ID: | 89122 |
| NCBI Accession: | Q9C037.2 |
| UniProt Secondary Accession: | Q9C037,Q75MK1, Q96F06, Q9C036, A4D298, |
| UniProt Related Accession: | Q9C037 |
| Molecular Weight: | 34,194 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase TRIM4 |
| NCBI Synonym Full Names: | tripartite motif containing 4 |
| NCBI Official Symbol: | TRIM4 |
| NCBI Official Synonym Symbols: | RNF87 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM4 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM4 |
| UniProt Synonym Protein Names: | RING finger protein 87; Tripartite motif-containing protein 4 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | TRIM4 |
| UniProt Entry Name: | TRIM4_HUMAN |
 | Western blot analysis of extracts of A375 cells, using TRIM4 antibody (CAB15922) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
 | Immunohistochemistry of paraffin-embedded Human placenta using TRIM4 Rabbit pAb (CAB15922) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using TRIM4 antibody (CAB15922) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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