Immunology Antibodies 2

Anti-TRIM38 Antibody (CAB2600)

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SKU:
CAB2600
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-TRIM38 Antibody
Antibody SKU:CAB2600
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 266-465 of human TRIM38 (NP_006346.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:A-549, HeLa, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 266-465 of human TRIM38 (NP_006346.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VSLE LHTM CNVS KLYF DVKK MLRS HQVS VTLD PDTA HHEL ILSE DRRQ VTRG YTQE NQDT SSRR FTAF PCVL GCEG FTSG RRYF EVDV GEGT GWDL GVCM ENVQ RGTG MKQE PQSG FWTL RLCK KKGY VALT SPPT SLHL HEQP LLVG IFLD YEAG VVSF YNGN TGCH IFTF PKAS FSDT LRPY FQVY QYSP LFLP PPGD
Gene ID:10475
Uniprot:O00635
Cellular Location:
Calculated MW:53kDa
Observed MW:53kDa
Synonyms:TRIM38, RNF15, RORET
Background:This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4.
UniProt Protein Function:TRIM38: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. {ECO:0000269|PubMed:23056470}
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol

Molecular Function:protein binding; signal transducer activity

Biological Process: activation of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; positive regulation of virion penetration into host cell

NCBI Summary:This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
UniProt Code:O00635
NCBI GenInfo Identifier:21362879
NCBI Gene ID:10475
NCBI Accession:O00635.1
UniProt Secondary Accession:O00635,B2R862,
UniProt Related Accession:O00635
Molecular Weight:53,416 Da
NCBI Full Name:E3 ubiquitin-protein ligase TRIM38
NCBI Synonym Full Names:tripartite motif containing 38
NCBI Official Symbol:TRIM38  
NCBI Official Synonym Symbols:RNF15; RORET  
NCBI Protein Information:E3 ubiquitin-protein ligase TRIM38
UniProt Protein Name:E3 ubiquitin-protein ligase TRIM38
UniProt Synonym Protein Names:RING finger protein 15; Tripartite motif-containing protein 38; Zinc finger protein RoRet
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:TRIM38  
UniProt Entry Name:TRI38_HUMAN
Anti-TRIM38 Antibody (CAB2600)Western blot analysis of extracts of various cell lines, using TRIM38 antibody (CAB2600) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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