Cell Biology Antibodies 18

Anti-TRIM37 Antibody (CAB18307)

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SKU:
CAB18307
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TRIM37 Antibody
Antibody SKU:CAB18307
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human TRIM37.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse testis, Mouse pancreas, Rat testis
Immunogen:Recombinant protein of human TRIM37.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4591
Uniprot:O94972
Cellular Location:
Calculated MW:108kDa
Observed MW:135kDa
Anti-TRIM37 Antibody (CAB18307)Western blot - TRIM37 Polyclonal Antibody (CAB18307)
Synonyms:MUL, POB1, TEF3, TRIM37
Background:This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin.
UniProt Protein Function:TRIM37: E3 ubiquitin-protein ligase. Defects in TRIM37 are the cause of mulibrey nanism (MUL); also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cytoplasm; cytosol; ESC/E(Z) complex; peroxisome

Molecular Function:protein binding; protein homodimerization activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of centriole replication; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; protein autoubiquitination

Disease: Mulibrey Nanism

NCBI Summary:This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]
UniProt Code:O94972
NCBI GenInfo Identifier:55976224
NCBI Gene ID:4591
NCBI Accession:O94972.2
UniProt Secondary Accession:O94972,Q7Z3E6, Q8IYF7, Q8WYF7, A8K0V9, A8K8U4, A8MZ79 B4DGZ3, F8WEE6,
UniProt Related Accession:O94972
Molecular Weight:103,941 Da
NCBI Full Name:E3 ubiquitin-protein ligase TRIM37
NCBI Synonym Full Names:tripartite motif containing 37
NCBI Official Symbol:TRIM37  
NCBI Official Synonym Symbols:MUL; POB1; TEF3  
NCBI Protein Information:E3 ubiquitin-protein ligase TRIM37
UniProt Protein Name:E3 ubiquitin-protein ligase TRIM37
UniProt Synonym Protein Names:Mulibrey nanism protein
UniProt Gene Name:TRIM37  
UniProt Entry Name:TRI37_HUMAN
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