Name: Anti-TRIM22 Antibody (CAB5508)
Brand: Immunology Antibodies 2
SKU: CAB5508
Availability: OutOfStock

Antibody Name:	Anti-TRIM22 Antibody
Antibody SKU:	CAB5508
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 215-411 of human TRIM22 (NP_006065.2).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:100
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 215-411 of human TRIM22 (NP_006065.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NLAA ATDQ LVQQ RQDA STLI SDLQ RRLR GSSV EMLQ DVID VMKR SESW TLKK PKSV SKKL KSVF RVPD LSGM LQVL KELT DVQY YWVD VMLN PGSA TSNV AISV DQRQ VKTV RTCT FKNS NPCD FSAF GVFG CQYF SSGK YYWE VDVS GKIA WILG VHSK ISSL NKRK SSGF AFDP SVNY SKVY SRYR PQYG YWVI G
Gene ID:	10346
Uniprot:	Q8IYM9
Cellular Location:	Cajal body, Cytoplasm, Nucleus, Nucleus speckle
Calculated MW:	56kDa
Observed MW:	57kDa

Synonyms:

TRIM22, GPSTAF50, RNF94, STAF50

Background:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	TRIM22: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11p15 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein binding, bridging; protein kinase binding; transcription corepressor activity; transcription factor activity Biological Process: activation of NF-kappaB transcription factor; immune response; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; regulation of protein localization; regulation of transcription, DNA-dependent; response to virus
NCBI Summary:	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
UniProt Code:	Q8IYM9
NCBI GenInfo Identifier:	47606181
NCBI Gene ID:	10346
NCBI Accession:	Q8IYM9.1
UniProt Secondary Accession:	Q8IYM9,Q05CQ0, Q15521,
UniProt Related Accession:	Q8IYM9
Molecular Weight:	56,429 Da
NCBI Full Name:	E3 ubiquitin-protein ligase TRIM22
NCBI Synonym Full Names:	tripartite motif containing 22
NCBI Official Symbol:	TRIM22
NCBI Official Synonym Symbols:	RNF94; STAF50; GPSTAF50
NCBI Protein Information:	E3 ubiquitin-protein ligase TRIM22
UniProt Protein Name:	E3 ubiquitin-protein ligase TRIM22
UniProt Synonym Protein Names:	50 kDa-stimulated trans-acting factor; RING finger protein 94; Staf-50; Tripartite motif-containing protein 22
Protein Family:	E3 ubiquitin-protein ligase
UniProt Gene Name:	TRIM22
UniProt Entry Name:	TRI22_HUMAN