Cell Biology Antibodies 7
Anti-TREM1 Antibody (CAB16535)
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- SKU:
- CAB16535
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TREM1 Antibody |
| Antibody SKU: | CAB16535 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human TREM1 (NP_061113.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human TREM1 (NP_061113.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRKT RLWG LLWM LFVS ELRA ATKL TEEK YELK EGQT LDVK CDYT LEKF ASSQ KAWQ IIRD GEMP KTLA CTER PSKN SHPV QVGR IILE DYHD HGLL RVRM VNLQ VEDS GLYQ CVIY QPPK EPHM LFDR IRLV VTKG FSGT PGSN ENST QNVY KIPP TTTK ALCP LYTS PRTV TQAP PKST ADVS TPDS EINL TNVT DIIR VPVF NIVI LLAG GFLS KSLV FSVL FAVT LRSF VP |
| Gene ID: | 54210 |
| Uniprot: | Q9NP99 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 17kDa/25kDa/26kDa |
| Observed MW: | 26kDa |
| Synonyms: | TREM1, CD354, TREM-1 |
| Background: | This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to membrane; extracellular region; plasma membrane Molecular Function:receptor activity Biological Process: neutrophil chemotaxis; innate immune response; cytokine secretion during immune response; blood coagulation; leukocyte migration; chemokine metabolic process; humoral immune response |
| NCBI Summary: | This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NP99 |
| NCBI GenInfo Identifier: | 50401685 |
| NCBI Gene ID: | 54210 |
| NCBI Accession: | Q9NP99.1 |
| UniProt Secondary Accession: | Q9NP99,Q53FL8, Q5T2C9, Q86YU1, B4DWG2, K7EJW1, |
| UniProt Related Accession: | Q9NP99 |
| Molecular Weight: | 234 |
| NCBI Full Name: | Triggering receptor expressed on myeloid cells 1 |
| NCBI Synonym Full Names: | triggering receptor expressed on myeloid cells 1 |
| NCBI Official Symbol: | TREM1 |
| NCBI Official Synonym Symbols: | CD354; TREM-1 |
| NCBI Protein Information: | triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1 |
| UniProt Protein Name: | Triggering receptor expressed on myeloid cells 1 |
| UniProt Synonym Protein Names: | Triggering receptor expressed on monocytes 1; CD_antigen: CD354 |
| Protein Family: | Triggering receptor expressed on myeloid cells |
| UniProt Gene Name: | TREM1 |
| UniProt Entry Name: | TREM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TREM1 antibody (CAB16535) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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