Cell Biology Antibodies 1
Anti-TREM1 Antibody (CAB0292)
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- SKU:
- CAB0292
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TREM1 Antibody |
| Antibody SKU: | CAB0292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-130 of human TREM1 (NP_061113.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-130 of human TREM1 (NP_061113.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATKL TEEK YELK EGQT LDVK CDYT LEKF ASSQ KAWQ IIRD GEMP KTLA CTER PSKN SHPV QVGR IILE DYHD HGLL RVRM VNLQ VEDS GLYQ CVIY QPPK EPHM LFDR IR |
| Gene ID: | 54210 |
| Uniprot: | Q9NP99 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 17kDa/25kDa/26kDa |
| Observed MW: | 30kDa |
| Synonyms: | TREM1, CD354, TREM-1 |
| Background: | This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| UniProt Protein Function: | TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to membrane; extracellular region; plasma membrane Molecular Function:receptor activity Biological Process: neutrophil chemotaxis; innate immune response; cytokine secretion during immune response; blood coagulation; leukocyte migration; chemokine metabolic process; humoral immune response |
| NCBI Summary: | This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NP99 |
| NCBI GenInfo Identifier: | 50401685 |
| NCBI Gene ID: | 54210 |
| NCBI Accession: | Q9NP99.1 |
| UniProt Secondary Accession: | Q9NP99,Q53FL8, Q5T2C9, Q86YU1, B4DWG2, K7EJW1, |
| UniProt Related Accession: | Q9NP99 |
| Molecular Weight: | 234 |
| NCBI Full Name: | Triggering receptor expressed on myeloid cells 1 |
| NCBI Synonym Full Names: | triggering receptor expressed on myeloid cells 1 |
| NCBI Official Symbol: | TREM1 |
| NCBI Official Synonym Symbols: | CD354; TREM-1 |
| NCBI Protein Information: | triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1 |
| UniProt Protein Name: | Triggering receptor expressed on myeloid cells 1 |
| UniProt Synonym Protein Names: | Triggering receptor expressed on monocytes 1; CD_antigen: CD354 |
| Protein Family: | Triggering receptor expressed on myeloid cells |
| UniProt Gene Name: | TREM1 |
| UniProt Entry Name: | TREM1_HUMAN |
 | Western blot analysis of extracts of HL-60 cells, using TREM1 antibody (CAB0292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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