Signal Transduction Antibodies 2
Anti-TREH Antibody (CAB15397)
- SKU:
- CAB15397
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-TREH Antibody |
Antibody SKU: | CAB15397 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-556 of human TREH (NP_009111.2). |
Application: | WB |
Recommended Dilution: | WB 1:200 - 1:2000 |
Reactivity: | Human, Rat |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-556 of human TREH (NP_009111.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | NAFL CQAE ELMS NFYS RLGN DSQA TKYR ILRS QRLA ALNT VLWD EQTG AWFD YDLE KKKK NREF YPSN LTPL WAGC FSDP GVAD KALK YLED NRIL TYQY GIPT SLQK TGQQ WDFP NAWA PLQD LVIR GLAK APLR RAQE VAFQ LAQN WIRT NFDV YSQK SAMY EKYD VSNG GQPG GGGE YEVQ EGFG WTNG VVLM LLDR YGDR LTS |
Gene ID: | 11181 |
Uniprot: | O43280 |
Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
Calculated MW: | 62kDa/66kDa |
Observed MW: | Refer to figures |
Synonyms: | TREH, TRE, TREA, trehalase |
Background: | This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | TREH: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms. Belongs to the glycosyl hydrolase 37 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.1.28; Membrane protein, GPI anchor; Carbohydrate Metabolism - starch and sucrose; Hydrolase Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: anchored to plasma membrane; plasma membrane Molecular Function:alpha,alpha-trehalase activity Biological Process: polysaccharide digestion; organ morphogenesis; trehalose catabolic process; trehalose metabolic process; carbohydrate metabolic process; pathogenesis Disease: Trehalase Deficiency |
NCBI Summary: | This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | O43280 |
NCBI GenInfo Identifier: | 116284412 |
NCBI Gene ID: | 11181 |
NCBI Accession: | NP_009111.2 |
UniProt Secondary Accession: | O43280,Q32MB9, Q53FY8, |
UniProt Related Accession: | O43280 |
Molecular Weight: | 62,941 Da |
NCBI Full Name: | trehalase isoform 1 |
NCBI Synonym Full Names: | trehalase (brush-border membrane glycoprotein) |
NCBI Official Symbol: | TREH |
NCBI Official Synonym Symbols: | TRE; TREA |
NCBI Protein Information: | trehalase; alpha,alpha-trehalose glucohydrolase |
UniProt Protein Name: | Trehalase |
UniProt Synonym Protein Names: | Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase |
Protein Family: | Trehalase |
UniProt Gene Name: | TREH |
UniProt Entry Name: | TREA_HUMAN |
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