Cell Death Antibodies 1

Anti-TRAF7 Antibody (CAB3095)

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SKU:
CAB3095
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-TRAF7 Antibody
Antibody SKU:CAB3095
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human TRAF7
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse
Positive Samples:Mouse fetal stomach
Immunogen:A synthetic peptide of human TRAF7
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84231
Uniprot:Q6Q0C0
Cellular Location:Cytoplasmic vesicle
Calculated MW:66kDa/74kDa
Observed MW:70kDa
Synonyms:TRAF7, RFWD1, RNF119
Background:
UniProt Protein Function:TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ligase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; nucleus; cytosol; ubiquitin ligase complex

Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: positive regulation of protein sumoylation; regulation of protein localization; positive regulation of MAPKKK cascade; transcription, DNA-dependent; apoptosis; activation of MAPKKK activity; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
UniProt Code:Q6Q0C0
NCBI GenInfo Identifier:54036486
NCBI Gene ID:84231
NCBI Accession:Q6Q0C0.1
UniProt Secondary Accession:Q6Q0C0,Q9H073,
UniProt Related Accession:Q6Q0C0
Molecular Weight:670
NCBI Full Name:E3 ubiquitin-protein ligase TRAF7
NCBI Synonym Full Names:TNF receptor-associated factor 7, E3 ubiquitin protein ligase
NCBI Official Symbol:TRAF7  
NCBI Official Synonym Symbols:RFWD1; RNF119  
NCBI Protein Information:E3 ubiquitin-protein ligase TRAF7; RING finger protein 119; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1
UniProt Protein Name:E3 ubiquitin-protein ligase TRAF7
UniProt Synonym Protein Names:RING finger and WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:TRAF7  
UniProt Entry Name:TRAF7_HUMAN
Anti-TRAF7 Antibody (CAB3095)Western blot analysis of extracts of mouse fetal stomach, using TRAF7 antibody (CAB3095). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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