Cell Biology Antibodies 12

Anti-TRAF3IP1 Antibody (CAB8997)

(No reviews yet) Write a Review
SKU:
CAB8997
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TRAF3IP1 Antibody
Antibody SKU:CAB8997
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 386-625 of human TRAF3IP1 (NP_001132962.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, A-549, Mouse kidney, Mouse testis, Mouse brain, Mouse lung, Rat kidney, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 386-625 of human TRAF3IP1 (NP_001132962.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSNI RRIP RPGS ARPA PPRV KRQD SMEA LQMD RSGS GKTV SNVI TESH NSDN EEDD QFVV EAAP QLSE MSEI EMVT AVEL EEEE KHGG LVKK ILET KKDY EKLQ QSPK PGEK ERSL FESA WKKE KDIV SKEI EKLR TSIQ TLCK SALP LGKI MDYI QEDV DAMQ NELQ MWHS ENRQ HAEA LQQE QRIT DCAV EPLK AELA ELEQ LIKD QQDK ICAV KANI LKNE EKIQ KMVY SINL TSRR
Gene ID:26146
Uniprot:Q8TDR0
Cellular Location:Cell projection, Cytoplasm, cilium, cytoskeleton
Calculated MW:71kDa/78kDa
Observed MW:79kDa
Synonyms:TRAF3IP1, IFT54, MIP-T3, MIPT3, SLSN9
Background:The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9.
UniProt Protein Function:TRAF3IP1: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Belongs to the TRAF3IP1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Microtubule-binding

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: centrosome

Molecular Function:protein binding

Biological Process: cilium biogenesis; intraflagellar transport; kidney development; morphogenesis of a polarized epithelium; negative regulation of defense response to virus; negative regulation of interferon type I production; negative regulation of protein amino acid phosphorylation; negative regulation of protein complex assembly

UniProt Code:Q8TDR0
NCBI GenInfo Identifier:74727348
NCBI Gene ID:26146
NCBI Accession:Q8TDR0.1
UniProt Secondary Accession:Q8TDR0,Q6PCT1, Q7L8N9, Q9NRD6, Q9Y4Q1,
UniProt Related Accession:Q8TDR0
Molecular Weight:71,529 Da
NCBI Full Name:TRAF3-interacting protein 1
NCBI Synonym Full Names:TRAF3 interacting protein 1
NCBI Official Symbol:TRAF3IP1  
NCBI Official Synonym Symbols:IFT54; MIPT3; SLSN9; MIP-T3  
NCBI Protein Information:TRAF3-interacting protein 1
UniProt Protein Name:TRAF3-interacting protein 1
UniProt Synonym Protein Names:Interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; Microtubule-interacting protein associated with TRAF3; MIP-T3
Protein Family:TRAF3-interacting protein
UniProt Gene Name:TRAF3IP1  
UniProt Entry Name:MIPT3_HUMAN
Anti-TRAF3IP1 Polyclonal Antibody (CAB8997)Western blot analysis of extracts of various cell lines, using TRAF3IP1 antibody (CAB8997) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
View AllClose

0 Reviews

View AllClose

Related Products