Anti-TRAF2 Antibody (CAB20143)

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SKU:
CAB20143
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MGC:45012
Synonyms:
TRAP
Synonyms:
TRAP3
Synonyms:
TRAF2

Description

Product Name:TRAF2 Rabbit pAb
Product Code:CAB20143
Size:50uL, 100uL
Synonyms:MGC:45012, TRAP, TRAP3, TRAF2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human TRAF2.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, rat testis, mouse thymus
Immunogen:Recombinant protein of human TRAF2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7186
Uniprot:Q12933
Cellular Location:Cytoplasm
Calculated MW:53kDa/54kDa/55kDa/61kDa
Observed MW:53kDa
UniProt Protein Function:TRAF2: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with BIRC2 and BIRC3 N- terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, DAB2IP, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1- phosphate. Belongs to the TNF receptor-associated factor family. A subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligase; Ubiquitin conjugating system; Autophagy; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: internal side of plasma membrane; cytoplasm; vesicle membrane; cell cortex; cytosol; ubiquitin ligase complex; lipid raft

Molecular Function:identical protein binding; sphingolipid binding; zinc ion binding; CD40 receptor binding; ubiquitin-protein ligase activity; mitogen-activated protein kinase kinase kinase binding; tumor necrosis factor receptor binding; protein phosphatase binding; protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; thioesterase binding; protein complex binding; ligase activity

Biological Process: caspase activation; positive regulation of JNK activity; protein autoubiquitination; protein heterooligomerization; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; signal transduction; activation of NF-kappaB transcription factor; regulation of apoptosis; cellular protein complex assembly; tumor necrosis factor-mediated signaling pathway; positive regulation of interleukin-2 production; innate immune response; protein catabolic process; protein complex assembly; positive regulation of transcription factor activity; positive regulation of T cell activation; regulation of immunoglobulin secretion

UniProt Code:Q12933
NCBI GenInfo Identifier:22027614
NCBI Gene ID:
NCBI Accession:NP_663770
Molecular Weight:55.729
NCBI Full Name:
UniProt Protein Name:TNF receptor-associated factor 2
UniProt Synonym Protein Names:E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3
Protein Family:TNF receptor-associated factor
UniProt Gene Name:TRAF2  
UniProt Entry Name:TRAF2_HUMAN
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