Cell Biology Antibodies 2
Anti-TRADD Antibody (CAB1145)
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- SKU:
- CAB1145
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRADD Antibody |
| Antibody SKU: | CAB1145 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of mouse TRADD |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, Jurkat |
| Immunogen: | Recombinant protein of mouse TRADD |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 71609 |
| Uniprot: | Q15628 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | TRADD, Hs.89862 |
| Background: | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. |
| UniProt Protein Function: | TRADD: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. |
| UniProt Protein Details: | Protein type:Apoptosis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol; receptor complex; lipid raft Molecular Function:identical protein binding; protein binding; signal transducer activity; protein complex binding; kinase binding; tumor necrosis factor receptor binding; molecular adaptor activity Biological Process: positive regulation of hair follicle development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; tumor necrosis factor-mediated signaling pathway; induction of apoptosis via death domain receptors; apoptosis; protein heterooligomerization; positive regulation of apoptosis; signal transduction; activation of NF-kappaB transcription factor |
| NCBI Summary: | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15628 |
| NCBI GenInfo Identifier: | 6094511 |
| NCBI Gene ID: | 8717 |
| NCBI Accession: | Q15628.2 |
| UniProt Secondary Accession: | Q15628,Q52NZ1, B2RDS3, B3KQZ9, |
| UniProt Related Accession: | Q15628 |
| Molecular Weight: | 312 |
| NCBI Full Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| NCBI Synonym Full Names: | TNFRSF1A-associated via death domain |
| NCBI Official Symbol: | TRADD |
| NCBI Official Synonym Symbols: | Hs.89862 |
| NCBI Protein Information: | tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1 associated death domain protein |
| UniProt Protein Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| UniProt Synonym Protein Names: | TNFRSF1A-associated via death domain |
| Protein Family: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| UniProt Gene Name: | TRADD |
| UniProt Entry Name: | TRADD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRADD antibody (CAB1145) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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