Cell Biology Antibodies 15
Anti-TRABD2B Antibody (CAB18570)
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- SKU:
- CAB18570
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRABD2B Antibody |
| Antibody SKU: | CAB18570 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TRABD2B. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TRABD2B. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 666048 |
| Uniprot: | A6NFA1 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | Gm12824, Hkat, TRABD2B |
| Background: |
| UniProt Protein Function: | LOC388630: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. Belongs to the TIKI family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p33 Cellular Component: integral to plasma membrane Molecular Function:Wnt-protein binding; protein binding; metal ion binding; metalloendopeptidase activity Biological Process: Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; protein amino acid oxidation; metabolic process; proteolysis |
| UniProt Code: | A6NFA1 |
| NCBI GenInfo Identifier: | 303228327 |
| NCBI Gene ID: | 388630 |
| NCBI Accession: | NP_001181915.1 |
| UniProt Secondary Accession: | A6NFA1,I6U4Y0, |
| UniProt Related Accession: | A6NFA1 |
| Molecular Weight: | 57,421 Da |
| NCBI Full Name: | metalloprotease TIKI2 |
| NCBI Synonym Full Names: | TraB domain containing 2B |
| NCBI Official Symbol: | TRABD2B |
| NCBI Official Synonym Symbols: | TIKI2 |
| NCBI Protein Information: | metalloprotease TIKI2 |
| UniProt Protein Name: | Metalloprotease TIKI2 |
| UniProt Synonym Protein Names: | Heart, kidney and adipose-enriched transmembrane protein homolog; TRAB domain-containing protein 2B |
| Protein Family: | Metalloprotease |
| UniProt Gene Name: | TRABD2B |
| UniProt Entry Name: | TIKI2_HUMAN |
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