Cell Biology Antibodies 10

Anti-TPD52L1 Antibody (CAB6420)

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SKU:
CAB6420
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TPD52L1 Antibody
Antibody SKU:CAB6420
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human TPD52L1 (NP_001003396.1).
Application:IF
Recommended Dilution:IF 1:20 - 1:50
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human TPD52L1 (NP_001003396.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEAQ AQGL LETE PLQG TDED AVAS ADFS SMLS EEEK EELK AELV QLED EITT LRQV LSAK ERHL VEIK QKLG MNLM NELK QNFS KSWH DMQT TTAY KKTH ETLS HAGQ KATA AFSN VGTA ISKK FGDM SYSI RHSI SMPA MRRK
Gene ID:7164
Uniprot:Q16890
Cellular Location:
Calculated MW:11kDa/14kDa/16kDa/19kDa/22kDa
Observed MW:
Synonyms:TPD52L1, D53
Background:This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed.
UniProt Protein Function:TPD52L1: a member of the tumor protein D52 (TPD52) family. Contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. Interacts with the apoptosis signal-regulating kinase 1 (ASK1) and positively regulates ASK1-induced apoptosis. Multiple alternatively spliced transcript variants have been observed.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: perinuclear region of cytoplasm; cytoplasm

Molecular Function:identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: positive regulation of MAP kinase activity; positive regulation of JNK cascade; G2/M transition of mitotic cell cycle; regulation of caspase activity

NCBI Summary:This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]
UniProt Code:Q16890
NCBI GenInfo Identifier:12585368
NCBI Gene ID:7164
NCBI Accession:Q16890.1
UniProt Related Accession:Q16890
Molecular Weight:
NCBI Full Name:Tumor protein D53
NCBI Synonym Full Names:TPD52 like 1
NCBI Official Symbol:TPD52L1  
NCBI Official Synonym Symbols:D53  
NCBI Protein Information:tumor protein D53
UniProt Protein Name:Tumor protein D53
UniProt Synonym Protein Names:Tumor protein D52-like 1
UniProt Gene Name:TPD52L1  
UniProt Entry Name:TPD53_HUMAN
Anti-TPD52L1 Antibody (CAB6420)Immunofluorescence analysis of U2OS cells using TPD52L1 antibody (CAB6420). Blue: DAPI for nuclear staining.
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