Cell Biology Antibodies 5
Anti-TPBG Antibody (CAB14790)
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- SKU:
- CAB14790
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TPBG Antibody |
| Antibody SKU: | CAB14790 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human TPBG (NP_006661.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse heart, Rat brain, Rat heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human TPBG (NP_006661.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SSPT SSAS SFSS SAPF LASA VSAQ PPLP DQCP ALCE CSEA ARTV KCVN RNLT EVPT DLPA YVRN LFLT GNQL AVLP AGAF ARRP PLAE LAAL NLSG SRLD EVRA GAFE HLPS LRQL DLSH NPLA DLSP FAFS GSNA SVSA PSPL VELI LNHI VPPE DERQ NRSF EGMV VAAL LAGR ALQG LRRL ELAS NHFL YLPR DVLA QLPS LRHL DLSN NSLV SLTY VSFR NLTH LESL HLED NALK VLHN GTLA ELQG LPHI RVFL DNNP WVCD CHMA DMVT WLKE TEVV QGKD RLTC AYPE KMRN RVLL ELNS ADLD CDPI LPP |
| Gene ID: | 7162 |
| Uniprot: | Q13641 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | TPBG, 5T4, 5T4AG, M6P1, WAIF1 |
| Background: | This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | Subcellular location: Membrane; Single-pass type I membrane protein |
| UniProt Protein Details: | Potential. Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy. Sequence similarities: Contains 6 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain. |
| NCBI Summary: | This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q13641 |
| NCBI GenInfo Identifier: | 262205665 |
| NCBI Gene ID: | 7162 |
| NCBI Accession: | NP_001159864.1 |
| UniProt Related Accession: | Q13641 |
| Molecular Weight: | 46,032 Da |
| NCBI Full Name: | trophoblast glycoprotein |
| NCBI Synonym Full Names: | trophoblast glycoprotein |
| NCBI Official Symbol: | TPBG |
| NCBI Official Synonym Symbols: | 5T4; M6P1; 5T4AG |
| NCBI Protein Information: | trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein |
| UniProt Protein Name: | Trophoblast glycoprotein |
| UniProt Synonym Protein Names: | 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1 |
| Protein Family: | Trophoblast glycoprotein |
| UniProt Gene Name: | TPBG |
| UniProt Entry Name: | TPBG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TPBG antibody (CAB14790) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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