Anti-TorsinA/TOR1A Antibody (CAB9579)

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SKU:
CAB9579
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DQ2
Synonyms:
DYT1
Research Area:
Cell Biology

Description

Product Name:TorsinA/TOR1A Rabbit mAb
Product Code:CAB9579
Size:20uL, 50uL, 100uL
Synonyms:DQ2, DYT1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TorsinA/TOR1A
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, U-87MG, Mouse liver, Mouse brain, Mouse spleen, Rat lung
Immunogen:A synthesized peptide derived from human TorsinA/TOR1A
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1861
Uniprot:O14656
Calculated MW:35kDa
Observed MW:38KDa
UniProt Protein Function:TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: synaptic vesicle; transport vesicle; nuclear membrane; growth cone; cytoskeleton; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule

Molecular Function:protein binding; kinesin binding; ATPase activity; cytoskeletal protein binding; unfolded protein binding; misfolded protein binding; ATP binding

Biological Process: protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; synaptic vesicle transport; regulation of dopamine uptake; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; nuclear membrane organization and biogenesis; neurite development; protein homooligomerization

Disease: Dystonia 1, Torsion, Autosomal Dominant

NCBI Summary:The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]
UniProt Code:O14656
NCBI GenInfo Identifier:13878817
NCBI Gene ID:1861
NCBI Accession:O14656.1
UniProt Secondary Accession:O14656,Q53Y64, Q96CA0, B2RB58,
UniProt Related Accession:O14656
Molecular Weight:37,809 Da
NCBI Full Name:Torsin-1A
NCBI Synonym Full Names:torsin family 1, member A (torsin A)
NCBI Official Symbol:TOR1A  
NCBI Official Synonym Symbols:DQ2; DYT1  
NCBI Protein Information:torsin-1A; torsin ATPase 1; torsin ATPase-1A; dystonia 1 protein; torsin family 1 member A; dystonia 1, torsion (autosomal dominant; torsin A)
UniProt Protein Name:Torsin-1A
UniProt Synonym Protein Names:Dystonia 1 protein; Torsin ATPase-1A (EC:3.6.4.-); Torsin family 1 member A
UniProt Gene Name:TOR1A  
UniProt Entry Name:TOR1A_HUMAN
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