Cell Biology Antibodies 5
Anti-TOB1 Antibody (CAB14835)
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- SKU:
- CAB14835
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TOB1 Antibody |
| Antibody SKU: | CAB14835 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TOB1 (NP_005740.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TOB1 (NP_005740.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQLE IQVA LNFI ISYL YNKL PRRR VNIF GEEL ERLL KKKY EGHW YPEK PYKG SGFR CIHI GEKV DPVI EQAS KESG LDID DVRG NLPQ DLSV WIDP FEVS YQIG EKGP VKVL YVDD NNEN GCEL DKEI KNSF NPEA QVFM |
| Gene ID: | 10140 |
| Uniprot: | P50616 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 38kDa |
| Observed MW: | 38kDa |
| Synonyms: | TOB1, APRO5, APRO6, PIG49, TOB, TROB, TROB1 |
| Background: | This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | TOB1: Anti-proliferative protein that interacts with the erbB- 2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. Belongs to the BTG family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Cell cycle regulation Chromosomal Location of Human Ortholog: 17q21 Cellular Component: CCR4-NOT complex Molecular Function:protein binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell proliferation; negative regulation of translation |
| NCBI Summary: | This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P50616 |
| NCBI GenInfo Identifier: | 1729989 |
| NCBI Gene ID: | 10140 |
| NCBI Accession: | P50616.1 |
| UniProt Secondary Accession: | P50616,Q4KMQ0, B2R9T0, D3DTY3, |
| UniProt Related Accession: | P50616 |
| Molecular Weight: | 38,155 Da |
| NCBI Full Name: | Protein Tob1 |
| NCBI Synonym Full Names: | transducer of ERBB2, 1 |
| NCBI Official Symbol: | TOB1 |
| NCBI Official Synonym Symbols: | TOB; TROB; APRO5; APRO6; PIG49; TROB1 |
| NCBI Protein Information: | protein Tob1 |
| UniProt Protein Name: | Protein Tob1 |
| UniProt Synonym Protein Names: | Transducer of erbB-2 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | TOB1 |
| UniProt Entry Name: | TOB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TOB1 antibody (CAB14835) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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