Cell Biology Antibodies 11
Anti-TNNI2 Antibody (CAB7937)
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- SKU:
- CAB7937
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TNNI2 Antibody |
| Antibody SKU: | CAB7937 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNNI2 (NP_003273.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNNI2 (NP_003273.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDE EKRN RAIT ARRQ HLKS VMLQ IAAT ELEK EESR REAE KQNY LAEH CPPL HIPG SMSE VQEL CKQL HAKI DAAE EEKY DMEV RVQK TSKE LEDM NQKL |
| Gene ID: | 7136 |
| Uniprot: | P48788 |
| Cellular Location: | |
| Calculated MW: | 21kDa |
| Observed MW: | 21kDa |
| Synonyms: | TNNI2, AMCD2B, DA2B, FSSV, fsTnI, troponin I2 |
| Background: | This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | TNNI2: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin I family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: troponin complex; cytosol; nucleus Molecular Function:troponin T binding; protein binding; actin binding Biological Process: skeletal muscle contraction; regulation of muscle contraction; positive regulation of transcription, DNA-dependent; muscle filament sliding Disease: Arthrogryposis, Distal, Type 2b |
| NCBI Summary: | This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P48788 |
| NCBI GenInfo Identifier: | 1351297 |
| NCBI Gene ID: | 7136 |
| NCBI Accession: | P48788.2 |
| UniProt Secondary Accession: | P48788,A6NIV8, A6NJU5, |
| UniProt Related Accession: | P48788 |
| Molecular Weight: | 182 |
| NCBI Full Name: | Troponin I, fast skeletal muscle |
| NCBI Synonym Full Names: | troponin I type 2 (skeletal, fast) |
| NCBI Official Symbol: | TNNI2 |
| NCBI Official Synonym Symbols: | DA2B; FSSV; fsTnI; AMCD2B |
| NCBI Protein Information: | troponin I, fast skeletal muscle; troponin I fast twitch 2; troponin I, skeletal, fast; troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform |
| UniProt Protein Name: | Troponin I, fast skeletal muscle |
| UniProt Synonym Protein Names: | Troponin I, fast-twitch isoform |
| Protein Family: | Troponin |
| UniProt Gene Name: | TNNI2 |
| UniProt Entry Name: | TNNI2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNNI2 antibody (CAB7937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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