Cell Biology Antibodies 11
Anti-TNNC2 Antibody (CAB7740)
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- SKU:
- CAB7740
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TNNC2 Antibody |
| Antibody SKU: | CAB7740 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TNNC2 (NP_003270.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-937, HT-29, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TNNC2 (NP_003270.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTDQ QAEA RSYL SEEM IAEF KAAF DMFD ADGG GDIS VKEL GTVM RMLG QTPT KEEL DAII EEVD EDGS GTID FEEF LVMM VRQM KEDA KGKS EEEL AECF RIFD RNAD GYID PEEL AEIF RASG EHVT DEEI ESLM KDGD KNND GRID FDEF LKMM EGVQ |
| Gene ID: | 7125 |
| Uniprot: | P02585 |
| Cellular Location: | |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | TNNC2, troponin C |
| Background: | Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. |
| UniProt Protein Function: | TNNC2: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Belongs to the troponin C family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q12-q13.11 Cellular Component: cytosol; troponin complex Molecular Function:actin binding; protein binding Biological Process: muscle filament sliding; regulation of muscle contraction; skeletal muscle contraction |
| NCBI Summary: | Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02585 |
| NCBI GenInfo Identifier: | 136043 |
| NCBI Gene ID: | 7125 |
| NCBI Accession: | P02585.2 |
| UniProt Secondary Accession: | P02585,Q6FH92, |
| UniProt Related Accession: | P02585 |
| Molecular Weight: | 18,122 Da |
| NCBI Full Name: | Troponin C, skeletal muscle |
| NCBI Synonym Full Names: | troponin C2, fast skeletal type |
| NCBI Official Symbol: | TNNC2 |
| NCBI Protein Information: | troponin C, skeletal muscle |
| UniProt Protein Name: | Troponin C, skeletal muscle |
| Protein Family: | Troponin |
| UniProt Gene Name: | TNNC2 |
| UniProt Entry Name: | TNNC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNNC2 antibody (CAB7740) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded human colon using TNNC2 antibody (CAB7740) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using TNNC2 antibody (CAB7740) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using TNNC2 antibody (CAB7740) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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