Metabolism Antibodies 2

Anti-TNKS2 Antibody (CAB16575)

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SKU:
CAB16575
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-TNKS2 Antibody
Antibody SKU:CAB16575
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:mouse liver, mouse kidney, rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TPLD LVSA DDVS ALLT AAMP PSAL PSCY KPQV LNGV RSPG ATAD ALSS GPSS PSSL SAAS SLDN LSGS FSEL SSVV SSSG TEGA SSLE KKEV PGVD FSIT QFVR NLGL EHLM DIFE REQI TLDV LVEM GHKE LKEI GINA YGHR HKLI KGVE RLIS GQQG LNPY LTLN TSGS GTIL IDLS PDDK EFQS VEEE MQST VREH RDGG HAGG IFNR YNIL KIQK VCNK KLWE RYTH RRKE VSEE NHNH ANER MLFH GSPF VNAI IHKG FDER HAY
Gene ID:80351
Uniprot:Q9H2K2
Cellular Location:Chromosome, Cytoplasm, Golgi apparatus membrane, Nucleus, Peripheral membrane protein, telomere
Calculated MW:126kDa
Observed MW:126kDa
Synonyms:TNKS2, ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6
Background:
UniProt Protein Function:TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
UniProt Protein Details:

Protein type:Nuclear envelope; EC 2.4.2.30; Transferase

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: Golgi membrane; pericentriolar material; nuclear chromosome, telomeric region; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; nucleus; cytosol

Molecular Function:protein binding; enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; protein polyubiquitination; Wnt receptor signaling pathway; multicellular organism growth; regulation of multicellular organism growth; positive regulation of telomere maintenance via telomerase

UniProt Code:Q9H2K2
NCBI GenInfo Identifier:13376842
NCBI Gene ID:80351
NCBI Accession:NP_079511.1
UniProt Secondary Accession:Q9H2K2,Q9H8F2, Q9HAS4, B2RBD3,
UniProt Related Accession:Q9H2K2
Molecular Weight:126,918 Da
NCBI Full Name:tankyrase-2
NCBI Synonym Full Names:tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
NCBI Official Symbol:TNKS2  
NCBI Official Synonym Symbols:TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c  
NCBI Protein Information:tankyrase-2; ADP-ribosyltransferase diphtheria toxin-like 6; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase 5B; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein
UniProt Protein Name:Tankyrase-2
UniProt Synonym Protein Names:ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein
Protein Family:Tankyrase
UniProt Gene Name:TNKS2  
UniProt Entry Name:TNKS2_HUMAN
Anti-TNKS2 Antibody (CAB16575)Western blot analysis of extracts of various cell lines, using TNKS2 antibody (CAB16575) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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